{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:32:40Z","timestamp":1788827560575,"version":"build-2803163510"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,1,13]],"date-time":"2016-01-13T00:00:00Z","timestamp":1452643200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:p>Endocervicosis is a rare benign condition characterized by the presence of endocervical\u2010type mucinous glands. Urinary bladder endocervicosis forms an elevated lesion in the posterior wall of the urinary bladder and is sometimes misdiagnosed as a malignant tumor clinically and pathologically. Herein we describe the first case of adenocarcinoma arising in urinary bladder endocervicosis. The patient, a 58\u2010year\u2010old woman, presented with asymptomatic hematuria. Cystoscopy revealed a nodular mass measuring 4\u2009cm in diameter in the posterior wall, and total cystectomy was performed. Histology revealed that the elevated lesion of the bladder wall was composed of haphazard proliferation of cystic glands lined by benign endocervical\u2010type epithelium. An adenocarcinoma arose at the center of this endocervicosis. Mucin histochemistry revealed the presence of sulfomucin in both the endocervicosis and adenocarcinoma components. Immunohistochemically, the endocervicosis was positive for cytokeratin (<jats:styled-content style=\"fixed-case\">CK<\/jats:styled-content>) 7, <jats:styled-content style=\"fixed-case\">AE<\/jats:styled-content>1\/<jats:styled-content style=\"fixed-case\">AE<\/jats:styled-content>3, <jats:styled-content style=\"fixed-case\">CAM<\/jats:styled-content>5.2, <jats:styled-content style=\"fixed-case\">HBME<\/jats:styled-content>1, <jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>19\u20109, and estrogen receptor (<jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content>), and negative for <jats:styled-content style=\"fixed-case\">CK<\/jats:styled-content>20, <jats:styled-content style=\"fixed-case\">CDX<\/jats:styled-content>2, progesterone receptor (<jats:styled-content style=\"fixed-case\">PR<\/jats:styled-content>), <jats:styled-content style=\"fixed-case\">MUC<\/jats:styled-content>5<jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content>, and \u03b2\u2010catenin. The adenocarcinoma showed similar immunohistochemical results, except for loss of <jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content> expression and a slight increase in the ratio of <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>i\u201067\u2010positive cells. This case indicates that endocervicosis, known as a benign lesion, harbors the possibility of malignant transformation.<\/jats:p>","DOI":"10.1111\/pin.12375","type":"journal-article","created":{"date-parts":[[2016,1,14]],"date-time":"2016-01-14T03:34:20Z","timestamp":1452742460000},"page":"108-113","source":"Crossref","is-referenced-by-count":18,"title":["Adenocarcinoma arising in urinary bladder endocervicosis"],"prefix":"10.1111","volume":"66","author":[{"given":"Masato","family":"Nakaguro","sequence":"first","affiliation":[{"name":"Department of Pathology Tosei General Hospital  Seto Japan"},{"name":"Department of Pathology and Laboratory Medicine Nagoya University Hospital  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toyonori","family":"Tsuzuki","sequence":"additional","affiliation":[{"name":"Department of Pathology Japanese Red Cross Nagoya Daini Hospital  Nagoya 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