{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T22:37:29Z","timestamp":1784068649679,"version":"3.55.0"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,1,25]],"date-time":"2016-01-25T00:00:00Z","timestamp":1453680000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:p>We present three cases of sclerosing mesenteritis and review the literature to learn whether or not sclerosing mesenteritis is an <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>4\u2010related disease (<jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>4\u2010<jats:styled-content style=\"fixed-case\">RD<\/jats:styled-content>). Our patients were all adult males. Their mesenteric masses ranged from 6.5 to 14.5\u2009cm in the greatest diameter. Tissue specimens showed moderate to severe lymphoplasmacytic infiltration with occasional eosinophils against a background of irregular fibrosis. Both obliterative phlebitis and storiform fibrosis were noted in all cases. <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>4+ plasma cells were moderately increased in number (46 to 85 cells\/high\u2010power field). However, unlike <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>4\u2010<jats:styled-content style=\"fixed-case\">RD<\/jats:styled-content>, the <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>4+\/<jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>+ plasma cell ratio was &lt;40% (28% to 35%). Serum <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>4 concentrations were also within the normal range (43.2 to 105\u2009mg\/dL; normal range &lt;135\u2009mg\/dL). Two biopsy cases showed spontaneous regression on imaging approximately 5 months later. No sclerosing conditions were found in other organs. The literature review identified 11 additional cases of sclerosing mesenteritis with <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>4+ plasma cell infiltration. However, conclusive cases with four characteristic features (high serum <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>4 levels, tissue <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>4 elevation, multi\u2010organ involvement, and effective response to glucocorticoid therapy) have never been reported. In conclusion, although sclerosing mesenteritis shares histological features with <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>4\u2010<jats:styled-content style=\"fixed-case\">RD<\/jats:styled-content>, most cases are less likely to be <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>4\u2010related. <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>4\u2010<jats:styled-content style=\"fixed-case\">RD<\/jats:styled-content> seemingly seldom, if ever, affects this anatomical site.<\/jats:p>","DOI":"10.1111\/pin.12386","type":"journal-article","created":{"date-parts":[[2016,1,26]],"date-time":"2016-01-26T01:18:49Z","timestamp":1453771129000},"page":"158-163","source":"Crossref","is-referenced-by-count":27,"title":["Sclerosing mesenteritis: A real manifestation or histological mimic of <scp>I<\/scp>g<scp>G<\/scp>4\u2010related disease?"],"prefix":"10.1111","volume":"66","author":[{"given":"Mehmet Ozgur","family":"Avincsal","sequence":"first","affiliation":[{"name":"Department of Diagnostic Pathology Kobe University Graduate School of Medicine  Kobe Japan"},{"name":"Department of Otolaryngology Kobe University Graduate School of Medicine  Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoko","family":"Otani","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Kobe University Graduate School of Medicine  Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maki","family":"Kanzawa","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Kobe University Graduate School of Medicine  Kobe Japan"},{"name":"Department of Pathology Kitaharima Medical Center  Ono 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