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However, it took some time to introduce this concept into pathology, where investigators count on formalin\u2010fixed paraffin\u2010embedded tissue sections. I sought out antigens for this purpose based on an oxidative stress\u2010induced rat renal carcinogenesis model, which revealed that 8\u2010hydroxy\u20102\u2032\u2010deoxyguanosine and 4\u2010hydroxy\u20102\u2010nonenal\u2010modified proteins are ideal. These two monoclonal antibodies successfully revealed the involvement of oxidative stress in numerous human diseases, including carcinogenesis and atherosclerosis. Shigeru Okada established the aforementioned ferric nitrilotriacetate (Fe\u2010NTA)\u2010induced rat renal carcinogenesis model, which thus far has answered many questions regarding the presence of target genes in oxidative stress\u2010induced carcinogenesis and the sites that are susceptible to oxidative stress in the genome. 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