{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T14:25:25Z","timestamp":1784039125423,"version":"3.55.0"},"reference-count":14,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,3,27]],"date-time":"2016-03-27T00:00:00Z","timestamp":1459036800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:p>Cancer of the ampulla of Vater is rare, though it has various histological types and its histogenesis is fascinating in view of the anatomically complex nature of the ampulla. Fetal gut\u2010like adenocarcinoma, usually found in the stomach, can also develop in the ampullary region in extremely rare cases. Here we present a case of ampullary adenocarcinoma with enteroblastic and neuroendocrine differentiation. A 55\u2010year\u2010old woman presented with an epigastric pain. Endoscopic examination revealed a 2\u2010cm submucosal tumor\u2010like lesion in the ampulla. The surgical specimen showed that an exposed protruding type of tumor appeared as a well\u2010demarcated whitish\u2010yellow solid mass. Microscopically, the tumor had proliferated in the common channel and invaded the duodenal submucosa with mucosal lesion of intestinal\u2010type adenocarcinoma. The main tumor consisted of three different histological types showing transitional areas: adenocarcinoma with enteroblastic differentiation (ENT), neuroendocrine carcinoma (NEC), and well differentiated adenocarcinoma (WEL). Morphologically the ENT resembled fetal gut and immunohistochemically expressed SALL4 and glypican 3. The WEL was positive for CK20 and CDX2, revealing an intestinal\u2010type phenotype. AFP and HepPar1 were not evident in any part of the lesion. We speculated this tumor had arisen from intestinal\u2010type adenocarcinoma of the common channel and acquired enteroblastic and neuroendocrine differentiation during growth.<\/jats:p>","DOI":"10.1111\/pin.12402","type":"journal-article","created":{"date-parts":[[2016,3,27]],"date-time":"2016-03-27T14:26:38Z","timestamp":1459088798000},"page":"230-235","source":"Crossref","is-referenced-by-count":14,"title":["A case of adenocarcinoma with enteroblastic differentiation of the ampulla of Vater"],"prefix":"10.1111","volume":"66","author":[{"given":"Koko","family":"Mitsuma","sequence":"first","affiliation":[{"name":"Division of Pathology and Clinical Laboratories"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirokazu","family":"Taniguchi","sequence":"additional","affiliation":[{"name":"Division of Pathology and Clinical Laboratories"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoji","family":"Kishi","sequence":"additional","affiliation":[{"name":"Hepato\u2010Biliary and Pancreatic Surgery Division National Cancer Center Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuyoshi","family":"Hiraoka","sequence":"additional","affiliation":[{"name":"Division of Pathology and Clinical Laboratories"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,3,27]]},"reference":[{"key":"e_1_2_4_2_1","volume-title":"Tumors of the Gallbladder, Extrahepatic Bile Ducts, and Ampulla of Vater. AFIP atlas of tumor pathology, third series, fascicle 27","author":"Albores\u2010Saavedra J","year":"2000"},{"key":"e_1_2_4_3_1","first-page":"87","volume-title":"WHO classification of tumors of the digestive system","author":"Albores\u2010Saavedra J","year":"2010"},{"key":"e_1_2_4_4_1","first-page":"48","volume-title":"WHO classification of tumors of the digestive system","author":"Lauwers GY","year":"2010"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/pin.12211"},{"key":"e_1_2_4_6_1","first-page":"38","volume-title":"WHO classification of tumours of the lung, pleura, thymus and heart","author":"Travis WD","year":"2015"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31823aafec"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1992.tb01044.x"},{"key":"e_1_2_4_9_1","first-page":"566","article-title":"Alpha\u2010fetoprotein\u2010producing cancer of the ampulla of Vater","volume":"39","author":"Sato Y","year":"1992","journal-title":"Hepatogastroenterology"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000116"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2009.01108.x"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181d1dcdd"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.11246"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2006.10.020"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.23600"}],"container-title":["Pathology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpin.12402","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pin.12402","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T16:49:06Z","timestamp":1695574146000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pin.12402"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,27]]},"references-count":14,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["10.1111\/pin.12402"],"URL":"https:\/\/doi.org\/10.1111\/pin.12402","archive":["Portico"],"relation":{},"ISSN":["1320-5463","1440-1827"],"issn-type":[{"value":"1320-5463","type":"print"},{"value":"1440-1827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,27]]}}}