{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T15:39:45Z","timestamp":1765294785898},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,5,8]],"date-time":"2016-05-08T00:00:00Z","timestamp":1462665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:p>Intratumoral ossification has been reported in a number of epithelial tumors, but its presence in intraductal papillary mucinous neoplasms (IPMNs) is very rare. Herein, we present a rare case of IPMN with marked ossification. A 56\u2010year\u2010old Japanese man was under follow\u2010up for a previously diagnosed IPMN. Seven years later, he was found to have dilatation of the main pancreatic duct and an enlarged solid mass, for which pancreaticoduodenectomy was performed. Macroscopically, multiple and cystically dilated pancreatic branch ducts, as well as a dilated main pancreatic duct, were identified. There was a solid, polypoid hard mass measuring 15 \u00d7 12 mm in the cystically dilated branch of the duct in the pancreatic head. Histological examination revealed papillary proliferation of atypical cuboidal or columnar epithelial cells in the dilated main and branch pancreatic ducts. The solid mass included an invasive adenocarcinoma component with a tubular or trabecular structure that showed pronounced ossification. We diagnosed the patient with invasive IPMN accompanied by marked ossification. Immunohistochemically, tumor cells in both the non\u2010invasive and invasive lesions expressed bone morphogenetic protein\u20102 (BMP\u20102). While the mechanism of intratumoral ossification is unclear, it may have involved BMP\u20102 in the present case.<\/jats:p>","DOI":"10.1111\/pin.12416","type":"journal-article","created":{"date-parts":[[2016,5,9]],"date-time":"2016-05-09T01:40:43Z","timestamp":1462758043000},"page":"343-347","source":"Crossref","is-referenced-by-count":3,"title":["Bone morphogenetic protein\u20102 expression in an intraductal papillary mucinous neoplasm with marked ossification: A case report"],"prefix":"10.1111","volume":"66","author":[{"given":"Atsuko","family":"Hadano","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Tokai University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenichi","family":"Hirabayashi","sequence":"additional","affiliation":[{"name":"Department of Pathology Tokai University School of 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