{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T22:43:09Z","timestamp":1789684989006,"version":"4.0.1"},"reference-count":39,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2016,9,11]],"date-time":"2016-09-11T00:00:00Z","timestamp":1473552000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006120","name":"Ministry of the Environment","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006120","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:p>\n                    Differentiation of malignant pleural mesothelioma (MPM) from benign mesothelial proliferation remains problematic. Loss of nuclear staining of BRCA1\u2010associated protein 1 (BAP1; detected using immunohistochemistry (IHC)) and homozygous deletion (HD) of\n                    <jats:italic>p16<\/jats:italic>\n                    (detected using fluorescence\n                    <jats:italic>in situ<\/jats:italic>\n                    hybridization (FISH)) are useful for differentiation of MPM from reactive mesothelial hyperplasia (RMH), but the correlation between BAP1 expression loss and\n                    <jats:italic>p16<\/jats:italic>\n                    HD has not been fully described. We performed BAP1 IHC and\n                    <jats:italic>p16<\/jats:italic>\n                    \u2010specific FISH for 40 MPM and 20 RMH cases, and measured proportions of cells showing BAP1 expression and\n                    <jats:italic>p16<\/jats:italic>\n                    HD for each case. The diagnostic accuracy for MPM and the cut\u2010off values of the two methods were assessed using receiver operating characteristic (ROC) analysis. BAP1 expression loss,\n                    <jats:italic>p16<\/jats:italic>\n                    HD and coexistence of both were present in 27 (67.5 %), 27 (67.5 %) and 17 (42.5 %) MPM cases, respectively. Three MPM cases (7.5 %) and all 20 RMH cases had neither BAP1 loss nor\n                    <jats:italic>p16<\/jats:italic>\n                    HD. There was no correlation between the results of the two methods. Their combination showed higher sensitivity (92.5 %, 37\/40) and estimated probability than BAP1 IHC and\n                    <jats:italic>p16<\/jats:italic>\n                    \u2010specific FISH used alone. BAP1 IHC and\n                    <jats:italic>p16<\/jats:italic>\n                    \u2010specific FISH have independent diagnostic value, and have increased reliability when used in combination, for MPM diagnosis.\n                  <\/jats:p>","DOI":"10.1111\/pin.12453","type":"journal-article","created":{"date-parts":[[2016,9,11]],"date-time":"2016-09-11T07:26:45Z","timestamp":1473578805000},"page":"563-570","source":"Crossref","is-referenced-by-count":74,"title":["BAP1 immunohistochemistry and\n                    <i>p16<\/i>\n                    FISH results in combination provide higher confidence in malignant pleural mesothelioma diagnosis: ROC analysis of the two tests"],"prefix":"10.1111","volume":"66","author":[{"given":"Tomoyuki","family":"Hida","sequence":"first","affiliation":[{"name":"Department of Pathology Fukuoka University Hospital and School of Medicine  Fukuoka Japan"},{"name":"Department of Anatomic Pathology, Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"},{"name":"Department of Clinical Radiology, Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Hamasaki","sequence":"additional","affiliation":[{"name":"Department of Pathology Fukuoka University Hospital and School of Medicine  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinji","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Pathology Fukuoka University Hospital and School of Medicine  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayuko","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Pathology Hyogo College of Medicine  Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tohru","family":"Tsujimura","sequence":"additional","affiliation":[{"name":"Department of Pathology Hyogo College of Medicine  Hyogo 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