{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T14:40:00Z","timestamp":1772808000572,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,2,13]],"date-time":"2017-02-13T00:00:00Z","timestamp":1486944000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:sec><jats:label\/><jats:p>Composite lymphomas (CLs) are defined as two unrelated lymphomas occurring at the same time within the same tissue. The incidence of these tumors is low. Of all possible combinations between lymphomas, the least frequent are the ones combining peripheral T\u2010cell lymphoma (PTCL) and Hodgkin lymphoma (HL). We recently identified five cases of CL composed of PTCL and classical HL, mixed cellularity type. We investigated histological and clinical features of these cases. Immunostaining was performed on paraffin sections. PTCL cells were positive for CD8 and TIA\u20101 in four of the five cases. Hodgkin and Reed\u2010Sternberg (HRS) cells were positive for CD30 and weakly positive for PAX5 in all cases, positive for CD15 in three of five cases, positive for CD20 in one of five cases, and negative for EBER. Monoclonal rearrangement of the T\u2010cell receptor (TCR) and immunoglobulin heavy chain (IGH) genes was confirmed by polymerase chain reaction (PCR) using whole paraffin sections. We concluded more precisely the monoclonality of the IGH rearrangement of HRS cells based on single\u2010cell PCR for IGH and DNA sequencing analysis after laser microdissection of single cells in one case. HL can occur in CD8\u2010positive and TIA\u20101\u2010positive PTCL. Clinicians should recognize the possibility of these CL.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pin.12515","type":"journal-article","created":{"date-parts":[[2017,2,13]],"date-time":"2017-02-13T07:52:50Z","timestamp":1486972370000},"page":"194-201","source":"Crossref","is-referenced-by-count":11,"title":["Composite lymphoma of peripheral T\u2010cell lymphoma and Hodgkin lymphoma, mixed cellularity type; pathological and molecular analysis"],"prefix":"10.1111","volume":"67","author":[{"given":"Ayako","family":"Ichikawa","sequence":"first","affiliation":[{"name":"Department of Pathology School of Medicine Kurume University Kurume Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Miyoshi","sequence":"additional","affiliation":[{"name":"Department of Pathology School of Medicine Kurume University Kurume Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuji","family":"Yamauchi","sequence":"additional","affiliation":[{"name":"Department of Medicine and Biosystemic Science Faculty of Medicine Kyushu University Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumiko","family":"Arakawa","sequence":"additional","affiliation":[{"name":"Department of Pathology School of Medicine Kurume University Kurume Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Riko","family":"Kawano","sequence":"additional","affiliation":[{"name":"Department of Pathology School of Medicine Kurume University Kurume Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroko","family":"Muta","sequence":"additional","affiliation":[{"name":"Department of Pathology School of Medicine Kurume University Kurume Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuo","family":"Sugita","sequence":"additional","affiliation":[{"name":"Department of Pathology School of Medicine Kurume University Kurume Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Akashi","sequence":"additional","affiliation":[{"name":"Department of Medicine and Biosystemic Science Faculty of Medicine Kyushu University Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Ohshima","sequence":"additional","affiliation":[{"name":"Department of Pathology School of Medicine Kurume University Kurume Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,2,13]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"554","volume-title":"Proc Second National Conf New York American Cancer Society","author":"Custer RP.","year":"1954"},{"key":"e_1_2_7_3_1","first-page":"1676","article-title":"Composite lymphoma","volume":"41","author":"Hendrickson KH","year":"1977","journal-title":"Cancer"},{"key":"e_1_2_7_4_1","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.5858\/2000-124-1376-AUVOCL","article-title":"An unusual variant of composite lymphoma","volume":"124","author":"Thirumala S","year":"2000","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAI.0b013e31817c551f"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910620103"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199603000-00013"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428190109064615"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2003.011882"},{"key":"e_1_2_7_10_1","doi-asserted-by":"crossref","first-page":"107","DOI":"10.5858\/2006-130-107-CLHLAP","article-title":"Composite lymphocyte\u2010rich hodgkin lymphoma and peripheral t\u2010cell lymphoma associated with epstein\u2010barr virus: A case report and review of the literature","volume":"130","author":"Sanchez S","year":"2006","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/1096-9896(2000)9999:9999<::AID-PATH651>3.0.CO;2-0"},{"key":"e_1_2_7_12_1","volume-title":"World Health Organization Classification of Tumours of Haematopoietic and Lymphoid Tissues","author":"Swerdlow SH","year":"2008"},{"key":"e_1_2_7_13_1","first-page":"1259","article-title":"Epstein\u2010Barr virus and Hodgkin's disease: A correlative in situ hybridization and polymerase chain reaction study","volume":"139","author":"Weiss LM","year":"1991","journal-title":"Am J Pathol"},{"key":"e_1_2_7_14_1","first-page":"117","article-title":"A PCR assay for detecting clonal rearrangement of the TCR\u2010gamma gene","volume":"6","author":"Lamberson C","year":"2001","journal-title":"Mol Diagn"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403202"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.45.9.770"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00019606-199303000-00007"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V84.10.3291.3291"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.2011.02662.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.2353\/jmoldx.2007.050121"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/00019606-200206000-00004"},{"key":"e_1_2_7_22_1","doi-asserted-by":"crossref","first-page":"S21","DOI":"10.1093\/annonc\/9.suppl_5.S21","article-title":"Immune escape mechanisms in Hodgkin's disease","volume":"9","author":"Poppema S","year":"1998","journal-title":"Annu Oncol"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.2711"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/756353"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-01-0099"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.11301"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199910000-00008"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1159\/000051636"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V92.4.1165"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19910315)67:6<1622::AID-CNCR2820670625>3.0.CO;2-1"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31822832de"}],"container-title":["Pathology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpin.12515","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pin.12515","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T19:49:58Z","timestamp":1696189798000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pin.12515"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,13]]},"references-count":30,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["10.1111\/pin.12515"],"URL":"https:\/\/doi.org\/10.1111\/pin.12515","archive":["Portico"],"relation":{},"ISSN":["1320-5463","1440-1827"],"issn-type":[{"value":"1320-5463","type":"print"},{"value":"1440-1827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,13]]}}}