{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T11:02:34Z","timestamp":1775559754681,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,6,11]],"date-time":"2017-06-11T00:00:00Z","timestamp":1497139200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:sec><jats:label\/><jats:p>We present a case of primary hepatic choriocarcinoma in an 83\u2010year\u2010old Japanese woman with gastric wall and lymph node metastases and a splenic vein tumor thrombus. Multiple irregular hepatic tumors with massive necrosis and hemorrhage were observed during autopsy. Syncytiotrophoblast\u2010like and mononucleated cytotrophoblast\u2010like cell morphology with focal hepatocellular carcinoma (HCC)\u2010like trabecular structures was observed. In immunohistochemical analyses, the tumor cells expressed human chorionic gonadotropin (hCG) and cytokeratins (AE1\/AE3, CK7, CK19) but were negative for alpha\u2010fetoprotein (AFP), glypican\u20103, and vimentin. Immunohistochemical findings did not reveal evidence of HCC or angiosarcoma. We concluded the liver tumor was primary hepatic choriocarcinoma.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pin.12552","type":"journal-article","created":{"date-parts":[[2017,6,12]],"date-time":"2017-06-12T00:42:37Z","timestamp":1497228157000},"page":"425-430","source":"Crossref","is-referenced-by-count":4,"title":["Primary hepatic choriocarcinoma in an 83\u2010year\u2010old woman"],"prefix":"10.1111","volume":"67","author":[{"given":"Akihiko","family":"Fukagawa","sequence":"first","affiliation":[{"name":"Department of Pathology Numazu City Hospital 550 Higashishiiji Harunoki Numazu Shizuoka 410\u20100302 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoto","family":"Fujita","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Numazu City Hospital 550 Higashishiiji Harunoki Numazu Shizuoka 410\u20100302 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