{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T13:45:31Z","timestamp":1782222331849,"version":"3.54.5"},"reference-count":17,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2017,6,30]],"date-time":"2017-06-30T00:00:00Z","timestamp":1498780800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:sec><jats:label\/><jats:p>Endometrial dedifferentiated carcinoma consists of a combination of undifferentiated and differentiated carcinomas. To date, clear cell carcinoma components in endometrial dedifferentiated carcinoma have not been reported. We report the first case of endometrial dedifferentiated carcinoma with clear cell carcinoma in a 58\u2010year\u2010old woman. The uterine corpus was completely replaced and enlarged by a heterogeneous mass. The endometrial cut surface showed a yellowish papillary growing mass involving endometrium and deeper myometrium. Microscopically, the three components (endometrioid carcinoma, FIGO grade 1, clear cell carcinoma and undifferentiated carcinoma) were noted with differentiated carcinoma components lining the endometrial cavity, while undifferentiated carcinoma components were identified in deeper endometrium and myometrium. Our histologic diagnosis was supported by the pattern of immunoreactivity. Tumor cells showed loss of expression of MLH1\/PMS2 protein and displayed high microsatellite\u2010instability in all three components. Furthermore, all three components including clear cell carcinoma had loss of PTEN and ARID1A expression. Our observations suggest that the three components derived from a monoclonal origin, as the three components had in common specific genetic alterations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pin.12557","type":"journal-article","created":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T04:26:36Z","timestamp":1498883196000},"page":"472-476","source":"Crossref","is-referenced-by-count":12,"title":["Dedifferentiated carcinoma with clear cell carcinoma of the endometrium: A case report"],"prefix":"10.1111","volume":"67","author":[{"given":"Seung Eun","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Pathology Konkuk University Medical Center Konkuk University School of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ha young","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Pathology Busan Paik Hospital Inje University College of Medicine Busan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung\u2010Hyuk","family":"Shim","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Konkuk University School of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wook Youn","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pathology Konkuk University Medical Center Konkuk University School of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,6,30]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pgp.0000183048.22588.18"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000171003.72352.9a"},{"key":"e_1_2_5_4_1","first-page":"5248","article-title":"A National Cancer Institute Workshop on Microsatellite Instability for cancer detection and familial predisposition: Development of international criteria for the determination of microsatellite instability in colorectal cancer","volume":"58","author":"Boland CR","year":"1998","journal-title":"Cancer Res"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21560"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12113"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000166"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2016.132"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.1999.5505"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800057"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(00)80244-0"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2011.208"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2013.67"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e318212782a"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.2911"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.12581"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/IGC.0000000000000092"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3182889dc3"}],"container-title":["Pathology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpin.12557","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pin.12557","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T19:55:20Z","timestamp":1696190120000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pin.12557"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,30]]},"references-count":17,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2017,9]]}},"alternative-id":["10.1111\/pin.12557"],"URL":"https:\/\/doi.org\/10.1111\/pin.12557","archive":["Portico"],"relation":{},"ISSN":["1320-5463","1440-1827"],"issn-type":[{"value":"1320-5463","type":"print"},{"value":"1440-1827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,30]]}}}