{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T17:27:59Z","timestamp":1762018079403},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,12,8]],"date-time":"2017-12-08T00:00:00Z","timestamp":1512691200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:sec><jats:label \/><jats:p>We report a colonic adenocarcinoma associated with diffuse submucosal deposition of a peculiar spheroid\u2010type amyloid identified in the colon, terminal ileum, and appendix. A 65\u2010year\u2010old woman with past medical histories of hypertension, and chronic obstructive pulmonary disease, presented to the emergency room with cramping abdominal pain and nausea. A computed tomography (CT) scan of abdomen showed right colonic volvulus. Emergency right hemicolectomy was performed. The specimen showed colonic adenocarcinoma with focal submucosal invasion (pT1) arising from a villotubular adenoma. A diffuse submucosal spheroid\u2010type amyloid deposition (resembling corpora amylacea\u2010like structures with Liesegang ring formation) was identified in the colon, ileum, and appendix. Electron microscopy examination of this unusual spheroidal\u2010type material further confirmed the presence of amyloid fibrils. Analysis by liquid chromatography\u2013mass spectrometry detected AL (lambda) type amyloidosis in this specimen. Tests for monoclonal gammopathy were not performed because patient consent was not obtained. In tissue section evaluation, however, no plasma cell neoplasm was identified. Cases with isolated AL amyloid deposition in the gastrointestinal tract have been reported rarely, and there is no case report of colonic adenocarcinoma associated with primary amyloid deposition in the English literature.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pin.12618","type":"journal-article","created":{"date-parts":[[2017,12,9]],"date-time":"2017-12-09T03:32:44Z","timestamp":1512790364000},"page":"123-127","source":"Crossref","is-referenced-by-count":10,"title":["Spheroid\u2010type of AL amyloid deposition associated with colonic adenocarcinoma: A case report with literature review"],"prefix":"10.1111","volume":"68","author":[{"given":"Moon Joo","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Pathology and Genomic Medicine Houston Methodist Hospital Weill Medical College of Cornell University Houston 77030 TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zulfia","family":"McCroskey","sequence":"additional","affiliation":[{"name":"Department of Pathology and Genomic Medicine Houston Methodist Hospital Weill Medical College of Cornell University Houston 77030 TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingchao","family":"Piao","sequence":"additional","affiliation":[{"name":"Department of Pathology and Genomic Medicine Houston Methodist Hospital Weill Medical College of Cornell University Houston 77030 TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Belcheva","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Weill Medical College of Cornell University Houston 77030 TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luan","family":"Truong","sequence":"additional","affiliation":[{"name":"Department of Pathology and Genomic Medicine Houston Methodist Hospital Weill Medical College of Cornell University Houston 77030 TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul J.","family":"Kurtin","sequence":"additional","affiliation":[{"name":"Division of Hematopathology Mayo Clinic College of Medicine Rochester MN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae Y.","family":"Ro","sequence":"additional","affiliation":[{"name":"Department of Pathology and Genomic Medicine Houston Methodist Hospital Weill Medical College of Cornell University Houston 77030 TX"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,12,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1007\/BF02774636","article-title":"A case of primary amyloidosis confined to the small intestine","volume":"21","author":"Shimizu S","year":"1986","journal-title":"Gastroenterol Jpn"},{"key":"e_1_2_7_3_1","first-page":"207","article-title":"Primary amyloid tumors of the jejunum producing intestinal obstruction","volume":"39","author":"Hamaya K","year":"1989","journal-title":"Acta Pathol Jpn"},{"key":"e_1_2_7_4_1","first-page":"267","article-title":"Al\u2010type generalized amyloidosis showing a solitary duodenal tumor","volume":"39","author":"Yousuf M","year":"1992","journal-title":"Hepatogastroenterology"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/003130299105449"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2012.068155"},{"key":"e_1_2_7_7_1","first-page":"453","article-title":"Amyloid deposits in pituitary adenomas. 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