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The most frequently involved site of the GI tract was the duodenum followed by the jejunum and ileum, and only 15% of FL arising in the second part of the duodenum were localized there without scattered very small daughter lesions in other GI tract examined by double\u2010balloon endoscopy. The typical macroscopic appearance of GI\u2010FL was multiple white nodules. Microscopically, neoplastic cells were small\u2010 to medium\u2010sized lymphoid cells and formed neoplastic follicles. Most of the cases (&gt;95%) were histologically Grade 1 to 2 (low grade). Several pathological and molecular characteristics were seen in GI\u2010FL (especially duodenal FL) compared with nodal FL: immunoglobulin heavy chain deviation to VH4 and VH5; memory B\u2010cell immunophenotype; and molecular features shared by mucosa\u2010associated lymphoid tissue lymphoma. Considering the pathological and molecular uniqueness of this disease, GI\u2010FL should be separately managed from nodal FL.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pin.12621","type":"journal-article","created":{"date-parts":[[2018,1,2]],"date-time":"2018-01-02T05:40:32Z","timestamp":1514871632000},"page":"1-6","source":"Crossref","is-referenced-by-count":38,"title":["Gastrointestinal follicular lymphoma: Current knowledge and future challenges"],"prefix":"10.1111","volume":"68","author":[{"given":"Katsuyoshi","family":"Takata","sequence":"first","affiliation":[{"name":"Department of Lymphoid Cancer Research British Columbia Cancer Research Centre Vancouver Canada"},{"name":"Department of Pathology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoko","family":"Miyata\u2010Takata","sequence":"additional","affiliation":[{"name":"Department of Pathology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuharu","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Pathology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaya","family":"Iwamuro","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Okada","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Tari","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hiroshima Red Cross Hospital and Atomic\u2010bomb Survivors Hospital Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadashi","family":"Yoshino","sequence":"additional","affiliation":[{"name":"Department of Pathology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,1,2]]},"reference":[{"key":"e_1_2_12_2_1","volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues WHO Classification of Tumours","author":"Swerdlow SH","year":"2017"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.13031"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199704000-00016"},{"key":"e_1_2_12_5_1","first-page":"1327","article-title":"Follicular lymphomas of the gastrointestinal tract. 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