{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T15:58:25Z","timestamp":1770134305021,"version":"3.49.0"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,2,25]],"date-time":"2018-02-25T00:00:00Z","timestamp":1519516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:sec><jats:label\/><jats:p>The anaplastic variant of diffuse large B\u2010cell lymphoma (A\u2010DLBCL) is morphologically defined but remains an enigmatic disease in its clinicopathologic distinctiveness. Here, we report two cases involving Japanese women aged 59 years, both with A\u2010DLBCL with the hallmark cell appearance and both indistinguishable from common and giant cell\u2010rich patterns, respectively, of anaplastic lymphoma kinase (ALK)\u2010positive anaplastic large cell lymphoma. Case 1 was immunohistochemically positive for CD20, CD79a and OCT\u20102 but not for the other pan\u2013B\u2010cell markers, CD30 and ALK. Case 2 showed CD20 and CD30 positivity for 50% and 20% of tumor cells in addition to strong expression of p53 and MYC. Both were positive for fascin without Epstein\u2013Barr virus association. Our cases provide additional support for the earlier reports that A\u2010DLBCL exhibits clinicopathologic features distinct from ordinal diffuse large B\u2010cell lymphoma (DLBCL), and documented its broader morphologic diversity than previously recognized. They also shed light on the unique feature of absent expression of pan\u2013B\u2010cell markers except for CD20 and CD79a, suggesting that A\u2010DLBCL may biologically mimic a gray zone or intermediate lymphoma between DLBCL and classic Hodgkin lymphoma.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pin.12653","type":"journal-article","created":{"date-parts":[[2018,2,26]],"date-time":"2018-02-26T06:08:34Z","timestamp":1519625314000},"page":"251-255","source":"Crossref","is-referenced-by-count":8,"title":["Anaplastic variant of diffuse large B\u2010cell lymphoma with hallmark cell appearance: Two cases highlighting a broad diversity in the diagnostics"],"prefix":"10.1111","volume":"68","author":[{"given":"Ayako","family":"Sakakibara","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Nagoya University Hospital Nagoya Japan"},{"name":"Department of Pathology Okazaki City Hospital Okazaki 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