{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T04:25:29Z","timestamp":1695529529818},"reference-count":15,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,3,23]],"date-time":"2018-03-23T00:00:00Z","timestamp":1521763200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["26893135"],"award-info":[{"award-number":["26893135"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:sec><jats:label \/><jats:p>Post\u2010mortem detection of pathogenetic microorganisms in severe infectious death is significantly important for diagnosing the cause of death as well as for public health. However, it is difficult to recognize whether a microorganism detected from post\u2010mortem materials is truly pathogenic or not. We report a case of severe soft tissue infection due to <jats:italic>Streptococcus oralis<\/jats:italic> subsp. <jats:italic>tigurinus<\/jats:italic> (<jats:italic>S. tigurinus<\/jats:italic>), a recently reported species, in which whole\u2010genome analysis was performed to clarify its pathogenicity. A 46\u2010year\u2010old woman had died with symptoms of a severe infectious disease. A post\u2010mortem examination was performed by a medical examiner. The external findings suggested a soft tissue infection; subsequently, pathological specimens sampled by necropsy revealed findings compatible with necrotizing fasciitis. In the post\u2010mortem bacterial test, <jats:italic>S. tigurinus<\/jats:italic> was detected from the localized autopsy sample. Whole\u2010genome sequencing was performed to analyze its pathogenicity and detected a strain of <jats:italic>S. tigurinus<\/jats:italic> with genetic determinants that were specific and unique to its highly virulent strains as a result of gene annotation. Utilizing various technologies, such as whole\u2010genome sequencing, may be a powerful tool for diagnosing the cause of infectious death accurately and safely.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pin.12656","type":"journal-article","created":{"date-parts":[[2018,3,23]],"date-time":"2018-03-23T20:04:09Z","timestamp":1521835449000},"page":"301-306","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A case of severe soft tissue infection due to <i>Streptococcus tigurinus<\/i> diagnosed by necropsy in which genomic analysis was useful for clarifying its pathogenicity"],"prefix":"10.1111","volume":"68","author":[{"given":"Hidenori","family":"Yoshizawa","sequence":"first","affiliation":[{"name":"Department of Legal Medicine Osaka University Graduate School of Medicine 2\u20102 Yamada\u2010oka Suita Osaka, 565\u20100871 Japan"},{"name":"Project for Death Control and Prevention Osaka University Graduate School of 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