{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T13:53:58Z","timestamp":1774014838483,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,7,10]],"date-time":"2018-07-10T00:00:00Z","timestamp":1531180800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:sec><jats:label\/><jats:p>Although gamma heavy chain disease (\u03b3\u2010HCD) lesions occasionally morphologically resemble angioimmunoblastic T\u2010cell lymphoma (AITL), no association has been described in detail due to the rarity of the disease. In this report, we present a rare manifestation of methotrexate (MTX)\u2010associated lymphoproliferative disorders (LPDs) with AITL\u2010like features accompanied by \u03b3\u2010HCD in a 75\u2010year\u2010old man with rheumatoid arthritis (RA). A biopsy specimen was evaluated using immunohistochemistry, clonal analyses of immunoglobulin V<jats:sub>H<\/jats:sub> and T\u2010cell receptor \u03b3 gene rearrangements by polymerase chain reaction, and Sanger sequencing for confirmation of the structure of deleted \u03b3\u2010HCD clones. The histological features characterized by proliferation of CD4\u2010 and PD\u20101\u2010positive medium\u2010sized T cells and arborizing high endothelial venules together with numbers of small lymphocytes, eosinophils, plasma cells, and histiocytes in the background mimicked those of AITL, but did not completely fulfill the diagnostic criteria. Clonal analysis demonstrated that the specimen contained multiple LPDs of both B\u2010cell and T\u2010cell lineages. Sequence analysis confirmed the co\u2010existence of a clone responsible for production of the abnormal heavy chain. This report provides new insights into the pathology of \u03b3\u2010HCD. Multiple host\u2010derived factors (e.g., RA and\/or use of MTX) may be responsible for the occurrence of LPDs of multiple lineages within a single lymph node.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pin.12703","type":"journal-article","created":{"date-parts":[[2018,7,10]],"date-time":"2018-07-10T08:47:52Z","timestamp":1531212472000},"page":"485-490","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Methotrexate\u2010associated lymphoproliferative disorders with angioimmunoblastic T\u2010cell lymphoma\u2010like features accompanied by gamma\u2010heavy chain disease in a patient with rheumatoid arthritis"],"prefix":"10.1111","volume":"68","author":[{"given":"Junichi","family":"Kiyasu","sequence":"first","affiliation":[{"name":"Department of Hematology Iizuka Hospital Iizuka Japan"},{"name":"Department of Pathology School of Medicine Kurume University Kurume Japan"},{"name":"Clinical Research Institute National Kyushu Cancer Center National Hospital Organization Fukuoka\u2010city Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumiko","family":"Arakawa","sequence":"additional","affiliation":[{"name":"Department of Pathology School of Medicine Kurume University Kurume Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shojiro","family":"Haji","sequence":"additional","affiliation":[{"name":"Department of Hematology Iizuka Hospital Iizuka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshimichi","family":"Tachikawa","sequence":"additional","affiliation":[{"name":"Department of Hematology Iizuka Hospital Iizuka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariko","family":"Tsuda","sequence":"additional","affiliation":[{"name":"Department of Hematology Iizuka Hospital Iizuka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiro","family":"Tsukamoto","sequence":"additional","affiliation":[{"name":"Department of Hematology Iizuka Hospital Iizuka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motohiko","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Department of Hematology Iizuka Hospital Iizuka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Muta","sequence":"additional","affiliation":[{"name":"Department of Hematology Iizuka Hospital Iizuka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takamitsu","family":"Matsushima","sequence":"additional","affiliation":[{"name":"Department of Hematology Iizuka Hospital Iizuka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Miyoshi","sequence":"additional","affiliation":[{"name":"Department of Pathology School of Medicine Kurume University Kurume Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motoaki","family":"Shiratsuchi","sequence":"additional","affiliation":[{"name":"Department of Medicine and Bioregulatory Science Graduate School of Medical Sciences Kyushu University Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiro","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Department of Medicine and Bioregulatory Science Graduate School of Medical Sciences Kyushu University Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kouichi","family":"Ohshima","sequence":"additional","affiliation":[{"name":"Department of Pathology School of Medicine Kurume University Kurume Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Yufu","sequence":"additional","affiliation":[{"name":"Department of Hematology Iizuka Hospital Iizuka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,7,10]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"237","volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","author":"Cook JR","year":"2016"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-198911000-00001"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.md.0000085058.63483.7f"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0215(20001101)88:3<497::AID-IJC27>3.0.CO;2-J"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000039746"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.2011.02662.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.12116"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.45.9.770"},{"key":"e_1_2_7_10_1","first-page":"462","volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","author":"Gaulard P","year":"2016"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2008.03.009"},{"key":"e_1_2_7_12_1","first-page":"453","volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","author":"Swerdlow SH","year":"2016"},{"key":"e_1_2_7_13_1","first-page":"403","volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","author":"Pileri SA","year":"2016"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2009.03.005"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2016.08.003"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780400317"}],"container-title":["Pathology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpin.12703","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pin.12703","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T12:45:35Z","timestamp":1695041135000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pin.12703"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,10]]},"references-count":15,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["10.1111\/pin.12703"],"URL":"https:\/\/doi.org\/10.1111\/pin.12703","archive":["Portico"],"relation":{},"ISSN":["1320-5463","1440-1827"],"issn-type":[{"value":"1320-5463","type":"print"},{"value":"1440-1827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,10]]},"assertion":[{"value":"2017-09-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-06-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-07-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}