{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T18:31:35Z","timestamp":1783362695006,"version":"3.54.6"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,11,19]],"date-time":"2018-11-19T00:00:00Z","timestamp":1542585600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec><jats:label\/><jats:p>Elderly patients with Epstein\u2010Barr virus (EBV) infection are at increased risk for developing B\u2010cell lymphoproliferative disorder (B\u2010LPD) due to immunosenescence. Here, we describe a case of a 75\u2010year\u2010old man who developed an EBV\u2010positive (EBV+) mucocutaneous ulcer (EBVMCU) in the gingiva with spontaneous regression. Eighteen months after regression, he had a cervical lymph node enlargement that was diagnosed as EBV+ nodal polymorphous B\u2010LPD, Ann Arbor stage IA. Clinicians decided to observe his clinical course without any treatment. Fourteen months later, the patient developed EBV\u2010positive diffuse large B\u2010cell lymphoma (DLBCL), Ann Arbor stage IIA, and received six courses of age\u2010adjusted dose chemotherapy and achieved a complete remission. No evidence of a clonal relationship was found among these three lesions by standard polymerase chain reaction (PCR) analysis for immunoglobulin heavy chain. However, they all had expression of PD\u2010L1 in the EBV+ large B\u2010cells and Hodgkin Reed\u2010Sternberg\u2010like cells. This is the first case report of a PD\u2010L1\u2010positive (PD\u2010L1+) EBVMCU and the development of multiple EBV\u2010driven B\u2010LPDs in the setting of immunosenescence within a 32\u2010month period.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pin.12738","type":"journal-article","created":{"date-parts":[[2018,11,19]],"date-time":"2018-11-19T11:05:16Z","timestamp":1542625516000},"page":"37-41","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Epstein\u2010Barr virus (EBV)\u2010positive diffuse large B\u2010cell lymphoma arising in patient with a history of EBV\u2010positive mucocutaneous ulcer and EBV\u2010positive nodal polymorphous B\u2010lymphoproliferative disorder"],"prefix":"10.1111","volume":"69","author":[{"given":"Teerada","family":"Daroontum","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Nagoya University Hospital Nagoya Japan"},{"name":"Department of Pathology 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