{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T06:16:17Z","timestamp":1792304177228,"version":"4.4.0"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,1,28]],"date-time":"2019-01-28T00:00:00Z","timestamp":1548633600000},"content-version":"vor","delay-in-days":27,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec><jats:label\/><jats:p>The clinicopathological and immunohistochemical characteristics of clinically occult extrapulmonary lymphangioleiomyomatosis in lymph nodes (LN\u2010LAM) being dissected during surgical staging of pelvic malignancy have not been well investigated. We assessed samples from nine female patients (median age, 61). None had past or familial history of tuberous sclerosis and had LAM lesions other than LN such as lung. The primary malignancies included four endometrial endometrioid carcinomas, one endometrial carcinosarcoma, three ovarian serous carcinomas and one urothelial carcinoma. Median follow\u2010up was 43 months. The number of affected LNs ranged from 1 to 15 (median, 2) with sizes ranging from 1 to 13\u2009mm (median, 3.0). Six cases had clinically occult LN\u2010LAM only within the pelvic LNs, two only within para\u2010aortic LNs, and one within both pelvic and para\u2010aortic lymph nodes. Immunohistochemically, LAM cells exhibited a strong diffuse positivity for \u03b2\u2010catenin and E\u2010cadherin in all nine cases. Clinically occult LN\u2010LAM mainly affects peri\u2010 or post\u2010menopausal women. On rare occasions, occult LN\u2010LAM may manifest as systemic LAM, including in the lung. \u03b2\u2010catenin and E\u2010cadherin carry potential utility as additional diagnostic markers.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pin.12749","type":"journal-article","created":{"date-parts":[[2019,1,28]],"date-time":"2019-01-28T10:25:32Z","timestamp":1548671132000},"page":"29-36","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Clinicopathological analysis of clinically occult extrapulmonary lymphangioleiomyomatosis in intra\u2010pelvic and para\u2010aortic lymph nodes associated with pelvic malignant tumors: A study of nine patients"],"prefix":"10.1111","volume":"69","author":[{"given":"Keiichiro","family":"Uehara","sequence":"first","affiliation":[{"name":"Department of Pathology Kobe City Medical Center General Hospital Kobe Japan"},{"name":"Department of Diagnostic Pathology Kobe University Hospital Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumi","family":"Kawakami","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Kobe University Hospital Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takanori","family":"Hirose","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Hyogo Cancer Center Akashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Morita","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Rokko Island Konan Hospital Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiji","family":"Kudo","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Tokushima Prefectural Central Hospital Tokushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanori","family":"Yasuda","sequence":"additional","affiliation":[{"name":"Department of Pathology Saitama Medical University International Medical Center Hidaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"M\u00e4rkl","sequence":"additional","affiliation":[{"name":"Institute of Pathology Klinikum Augsburg Augsburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoh","family":"Zen","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Kobe University Hospital Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoo","family":"Itoh","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Kobe University Hospital Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukihiro","family":"Imai","sequence":"additional","affiliation":[{"name":"Department of Pathology Kobe City Medical Center General Hospital Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,1,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199011013231807"},{"key":"e_1_2_7_3_1","first-page":"348","article-title":"Pulmonary lymphangiomyomatosis. 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