{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T07:25:49Z","timestamp":1774682749596,"version":"3.50.1"},"reference-count":10,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,2,5]],"date-time":"2019-02-05T00:00:00Z","timestamp":1549324800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:sec><jats:label\/><jats:p>Anaplastic large cell lymphoma (ALCL) with <jats:italic>TP63<\/jats:italic> rearrangement is a new entity and has the most dismal prognosis in all types of ALCL. This might be due to the resulting fusion protein having N\u2010terminal truncated p63 with high oncogenic ability. Since this N\u2010terminal domain has the function of tumor suppressor activity, the mechanism for high oncogenic capacity is thought to be the dominant negative function. Here, we report two ALCL cases with <jats:italic>TP63<\/jats:italic> rearrangement that was each given too short a prognosis (Case 1 and 2: four and six months) in spite of intensive treatment. Immunohistochemically, p63 was highly expressed, and a sprit signal was detected using a <jats:italic>TP63<\/jats:italic> break apart fluorescence in situ hybridization (FISH) in each case. Additionally, a poor prognostic marker of ALCL, all cytotoxic molecules (TIA\u20101, Granzyme B, and Perforin) were also expressed in almost all ALCL cells. Taken together, we suggest that not only the dominant negative function of N\u2010truncated p63 but also the effect of cytotoxic molecules may influence the dismal prognosis of ALCL with <jats:italic>TP63<\/jats:italic> rearrangement.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pin.12758","type":"journal-article","created":{"date-parts":[[2019,2,5]],"date-time":"2019-02-05T12:32:07Z","timestamp":1549369927000},"page":"155-159","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Anaplastic large cell lymphoma with <i>TP63<\/i> rearrangement: A dismal prognosis"],"prefix":"10.1111","volume":"69","author":[{"given":"Takahisa","family":"Yamashita","sequence":"first","affiliation":[{"name":"Department of Pathology Saitama Medical Center Saitama Medical University 1981 Kamoda Kawagoe\u2010shi Saitama 3508550 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