{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T10:20:05Z","timestamp":1758709205241},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:sec><jats:label \/><jats:p>\u03b22\u2010microglobulin\u2010related (A\u03b22M) amyloidosis (dialysis\u2010associated amyloidosis) is a common complication in long\u2010term dialysis patients. An increased concentration of \u03b22\u2010microgloblin (\u03b22\u2010m) in the serum appears to be a prerequisite for A\u03b22M amyloidosis, in turn causing A\u03b22M amyloid deposition predominantly in the osteoarticular tissue. There are few reports, however, of A\u03b22M amyloid deposition in non\u2010dialysis patients. We describe an atypical case of a non\u2010dialysis patient with A\u03b22M amyloid deposition in bladder cancer. A Japanese man in his 80s with no history of dialysis was admitted for transurethral resection of bladder cancer. Histopathological analysis revealed a small amount of amyloid deposition in the small\u2010vessel wall of both the peripheral urothelial carcinoma and necrotic area. Amyloid typing by immunohistochemistry was strongly positive for anti\u2010\u03b22\u2010m antibody, and \u03b22\u2010m was most frequently detected in laser microdissection\u2010liquid chromatography tandem mass spectrometry. Although A\u03b22M amyloidosis was expected, contrary to this, the patient's serum \u03b22\u2010m was only 4\u2009mg\/L, although his urine \u03b22\u2010m level was increased at 1340\u2009mg\/L. The unique findings observed in our patient may contribute to the elucidation of the novel pathogenesis of A\u03b22M amyloid fibril formation that is distinct from conventional A\u03b22M amyloidosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pin.12770","type":"journal-article","created":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T18:38:05Z","timestamp":1549046285000},"page":"224-228","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["An unusual case of A\u03b22M amyloid deposition in bladder cancer in a non\u2010dialysis patient"],"prefix":"10.1111","volume":"69","author":[{"given":"Aya","family":"Ishii","sequence":"first","affiliation":[{"name":"Department of Anatomic Pathology Kurashiki Central Hospital  Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhide","family":"Tei","sequence":"additional","affiliation":[{"name":"Department of Urology National Hospital Organization Kanmon Medical Center  Yamaguchi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoyuki","family":"Murakami","sequence":"additional","affiliation":[{"name":"Department of Pathology National Hospital Organization Kanmon Medical Center  Yamaguchi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Notohara","sequence":"additional","affiliation":[{"name":"Department of Anatomic Pathology Kurashiki Central Hospital  Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1986.196"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbapap.2005.09.006"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199010113231514"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000186661"},{"key":"e_1_2_8_6_1","first-page":"298","article-title":"Carpal\u2010tunnel syndrome with beta 2\u2010microglobulin amyloid deposits and erosive arthropathy of the wrist and spine in a uraemic patient before chronic haemodialysis","volume":"10","author":"Kessler M","year":"1995","journal-title":"Nephrol Dial Transplant"},{"key":"e_1_2_8_7_1","first-page":"1301","article-title":"Mechanisms of transthyretin amyloidogenesis. 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