{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T13:51:27Z","timestamp":1762005087704},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,2,19]],"date-time":"2019-02-19T00:00:00Z","timestamp":1550534400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:sec><jats:label \/><jats:p>We report a case of localized bronchial lactoferrin amyloidosis. A 47\u2010year\u2010old man presented with a complaint of persistent dry cough for two months. Chest computed\u2010tomography revealed a calcification shadow of the right main bronchus; hence, a biopsy was performed, showing layered spheroid\u2010type eosinophilic deposits in the bronchial wall. These deposits were positive for Congo red staining, exhibiting apple\u2010green birefringence under polarized light. In addition, an electron microscopic examination demonstrated that this layered structure was formed by very thin cord\u2010like amyloid deposits. By proteomics analysis using liquid chromatography\u2013tandem mass spectrometry and immunohistochemistry, we confirmed that the deposited amyloid was composed of lactoferrin. While lactoferrin is known to be a precursor protein of localized corneal and seminal vesicle amyloidosis, localized lactoferrin amyloidosis of the bronchus has not been reported in the English literature. Our pathological findings suggested that localized lactoferrin amyloidosis may be caused by long\u2010term tissue damage, and the characteristic spheroid\u2010type appearance is thought to be associated with unique, thin cord\u2010like amyloid deposits.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pin.12774","type":"journal-article","created":{"date-parts":[[2019,2,19]],"date-time":"2019-02-19T15:07:01Z","timestamp":1550588821000},"page":"235-240","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["A case of spheroid\u2010type localized lactoferrin amyloidosis in the bronchus"],"prefix":"10.1111","volume":"69","author":[{"given":"Shojiro","family":"Ichimata","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine Shinshu University Hospital  Matsumoto Japan"},{"name":"Department of Pathology Saku Central Hospital Advanced Care Center  Saku Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daiju","family":"Aoyagi","sequence":"additional","affiliation":[{"name":"Department of Pathology Saku Central Hospital Advanced Care Center  Saku Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsuneaki","family":"Yoshinaga","sequence":"additional","affiliation":[{"name":"Department of Neurology and Rheumatology Shinshu University School of Medicine  Matsumoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nagaaki","family":"Katoh","sequence":"additional","affiliation":[{"name":"Department of Neurology and Rheumatology Shinshu University School of Medicine  Matsumoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fuyuki","family":"Kametani","sequence":"additional","affiliation":[{"name":"Department of Dementia and Higher Brain Function Tokyo Metropolitan Institute of Medical Science  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahide","family":"Yazaki","sequence":"additional","affiliation":[{"name":"Institute for Biomedical Sciences Shinshu University  Matsumoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Uehara","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Shinshu University Hospital  Matsumoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Shiozawa","sequence":"additional","affiliation":[{"name":"Department of Pathology Saku Central Hospital Advanced Care Center  Saku Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,2,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra023144"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/13506129.2014.964858"},{"key":"e_1_2_8_4_1","doi-asserted-by":"crossref","DOI":"10.55418\/1881041794","volume-title":"Non\u2010Neoplastic Disorder of the Lower Respiratory Tract","author":"Travis WD","year":"2002"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.LAB.0000017170.26718.89"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2004.056804"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.1996.tb03643.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1827.2001.01198.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3109\/13506129.2015.1037389"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/003130299105449"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2012.068155"},{"key":"e_1_2_8_12_1","first-page":"453","article-title":"Amyloid deposits in pituitary adenomas. 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