{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,27]],"date-time":"2025-12-27T07:13:50Z","timestamp":1766819630882,"version":"3.40.5"},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,2,27]],"date-time":"2019-02-27T00:00:00Z","timestamp":1551225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:sec><jats:label\/><jats:p>Pleomorphic lobular carcinoma (PLC) of the breast is a variant of lobular carcinoma, characterized by loss of E\u2010cadherin expression and high\u2010grade morphologies. Whether the pathogenesis of PLC is in the ductal or the lobular lineage has been discussed. In this report, a case of PLC combined with apocrine carcinoma is presented. Histologically, the tumor showed two distinct carcinoma components: one was a typical apocrine carcinoma, and the other was a pleomorphic invasive lobular carcinoma. The former showed complete membranous expression of E\u2010cadherin, whereas the latter aberrantly expressed it not on the cell membrane, but in the cytoplasm. Both components were triple\u2010negative and strongly positive for GCDFP\u201015, suggesting apocrine differentiation. The intraductal component showed only a feature of apocrine ductal carcinoma in situ. This case suggests that apocrine carcinoma could be an origin of PLC.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pin.12781","type":"journal-article","created":{"date-parts":[[2019,2,27]],"date-time":"2019-02-27T19:14:17Z","timestamp":1551294857000},"page":"288-293","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Mixed pleomorphic lobular and apocrine carcinoma of the breast: A case report suggesting pathogenesis"],"prefix":"10.1111","volume":"69","author":[{"given":"Akiko","family":"Ishii","sequence":"first","affiliation":[{"name":"Division of Pathology Shizuoka Cancer Center Hospital Shizuoka Japan"},{"name":"Department of Pathology and Oncology Graduate School of Medicine University of the Ryukyus Okinawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuma","family":"Oishi","sequence":"additional","affiliation":[{"name":"Division of Pathology Shizuoka Cancer Center Hospital Shizuoka 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