{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T02:30:06Z","timestamp":1745980206003},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,4,16]],"date-time":"2019-04-16T00:00:00Z","timestamp":1555372800000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:p><jats:bold>We aimed to propose a biosafety algorithm for the protection of pathology staff during intraoperative examinations of pulmonary lesions when working with cytological imprints and\/or frozen sections for the intraoperative diagnosis of pulmonary lesions. We examined 148 pulmonary surgical tissues obtained intraoperatively for imprint cytology (IC) and for frozen sectioning and compared the diagnoses against the final pathological diagnoses. We analyzed concordance and non\u2010concordance rates and then used the data to produce a biosafety algorithm. The diagnostic sensitivity, specificity, positive predictive value, negative predictive value and accuracy of scratch\u2010IC were 91%, 100%, 100%, 50% and 92%, respectively, and those of frozen sectioning were 99%, 100%, 100%, 96% and 99%, respectively. Our data indicate that frozen sectioning is unnecessary if scratch\u2010IC yields a \u2018malignant\u2019 diagnosis but recommended with a \u2018benign\u2019 diagnosis. When a scratch\u2010IC preparation deemed inadequate for a diagnosis or an abscess, the pathologist must consult the surgeon concerning the possibility of granuloma with caseous necrosis and should ask the surgeon to be prepared for a frozen section. If granuloma with caseous necrosis is found in the frozen section, the pathologist must immediately communicate the information to entire staff and perform a PCR test before making a permanent section.<\/jats:bold><\/jats:p>","DOI":"10.1111\/pin.12789","type":"journal-article","created":{"date-parts":[[2019,4,16]],"date-time":"2019-04-16T17:21:07Z","timestamp":1555435267000},"page":"211-218","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A biosafety algorithm for the protection of pathology staff during intraoperative examinations of pulmonary lesions"],"prefix":"10.1111","volume":"69","author":[{"given":"Tomoko","family":"Sugiyama","sequence":"first","affiliation":[{"name":"Department of Diagnostic Pathology, Tokai University Hachioji Hospital, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuma","family":"Tajiri","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology, Tokai University Hachioji Hospital, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirotaka","family":"Fujita","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Tokai University Hachioji Hospital, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinichiro","family":"Hiraiwa","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology, Tokai University Hachioji Hospital, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suguru","family":"Toguchi","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Tokai University Hachioji Hospital, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nozomi","family":"Nomura","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Tokai University Hachioji Hospital, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohisa","family":"Machida","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Tokai University Hachioji Hospital, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Suga","sequence":"additional","affiliation":[{"name":"Department of General Thoracic Surgery Tokai University Hachioji Hospital Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of General Thoracic Surgery Tokai University Hachioji Hospital Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoki","family":"Nakagawa","sequence":"additional","affiliation":[{"name":"Department of General Thoracic Surgery Tokai University Hachioji Hospital Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shyunsuke","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of General Thoracic Surgery Tokai University Hachioji Hospital Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayuki","family":"Iwazaki","sequence":"additional","affiliation":[{"name":"Division of General Thoracic Surgery, Department of Surgery Tokai University School of Medicine Isehara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoya","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Pathology Tokai University School of Medicine Isehara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,4,16]]},"reference":[{"key":"e_1_2_7_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2006.02.063"},{"key":"e_1_2_7_1_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1102873"},{"key":"e_1_2_7_1_4_1","first-page":"7961","article-title":"Intraoperative pathology consultation for pulmonary lesions: Errors and deferrals","volume":"8","author":"Akyildiz EU.","year":"2015","journal-title":"Int J Clin Exp Pathol"},{"key":"e_1_2_7_1_5_1","doi-asserted-by":"publisher","DOI":"10.5858\/2005-129-1602-FSOLS"},{"key":"e_1_2_7_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2004.05.003"},{"key":"e_1_2_7_1_7_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.98.5.1156"},{"key":"e_1_2_7_1_8_1","first-page":"499","article-title":"Biosafety manual concerning tests on tuberculosis bacilli, the first edition, 2005: compiled by Committee for Testing Acid\u2010Fast Bacilli, the Japanese Society for Tuberculosis, the Japanese Society of Clinical Microbiology, and the Japanese Society of Clinical Technologists. 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