{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T21:06:20Z","timestamp":1694466380149},"reference-count":12,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,6,18]],"date-time":"2019-06-18T00:00:00Z","timestamp":1560816000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:p>We report a fulminant case of classical Hodgkin lymphoma (CHL). The patient died only approximately 2 months after the onset of subjective symptoms. Autopsy specimens revealed atypical cells resembling Hodgkin and Reed\u2010Sternberg (HRS) cells in a rich inflammatory background in various organs. There were marked, characteristic angiodestructive lesions from infiltrating HRS\u2010like cells and numerous macrophages. The HRS\u2010like cells were infected with Epstein\u2010Barr virus (EBV), immunohistochemically positive for PAX5 and CD30, and negative for CD3, CD20, and ALK. Most B\u2010cell markers other than PAX5 were negative, and the HRS\u2010like cells also expressed cytotoxic molecules. Monoclonal rearrangement of immunoglobulin heavy chain was detected by PCR analysis. According to the 2016 WHO classification, we diagnosed mixed cellularity CHL. However, EBV\u2010positive diffuse large B\u2010cell lymphoma (DLBCL), not otherwise specified and EBV\u2010positive B\u2010cell lymphoma, unclassifiable with features intermediate between DLBCL and CHL were considered as differential diagnoses because both tumors are aggressive EBV\u2010positive large B\u2010cell neoplasms with reactive inflammatory cells and sometimes contains HRS\u2010like cells. The clinical condition of the current case was closer to these two entities than to CHL. A diagnosis of EBV\u2010positive large B\u2010cell neoplasms was difficult because of overlapping morphological and immunohistochemical characteristics, but should be considered for prognosis.<\/jats:p>","DOI":"10.1111\/pin.12800","type":"journal-article","created":{"date-parts":[[2019,6,19]],"date-time":"2019-06-19T09:46:22Z","timestamp":1560937582000},"page":"407-413","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A fulminant case of classical Hodgkin lymphoma: A diagnostic dilemma of Epstein\u2010Barr virus\u2010positive large B\u2010cell neoplasms"],"prefix":"10.1111","volume":"69","author":[{"given":"Shojiro","family":"Ichimata","sequence":"first","affiliation":[{"name":"Department of Pathology Shinshu University School of Medicine  Matsumoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikiko","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of 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