{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T21:07:36Z","timestamp":1694466456809},"reference-count":11,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,6,24]],"date-time":"2019-06-24T00:00:00Z","timestamp":1561334400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:p>We report a case of an extremely rare type of duodenal gastrointestinal stromal tumor (GIST) that included neuronal components. Although gastrointestinal autonomic nerve tumors (GANTs), a subtype of GISTs, exhibit ultrastructural features of the nerve plexus, neuronal cells have not been observed within GANTs or GISTs. GISTs originate from interstitial cells of Cajal (ICCs), which are markedly different from the progenitor cells of neural elements and neural\u2010crest\u2010derived stem cells. This may explain why GISTs typically lack neuronal elements. It remains unclear that the neuronal components of this tumor are neoplastic or hyperplastic, but proliferation and survival of ICCs have recently been reported to be closely related to neurons. Although we could not find the <jats:italic>KIT, PDGFR<\/jats:italic>, and <jats:italic>BRAF<\/jats:italic> mutation as far as we examined, it may have had a rare mutation in <jats:italic>NF1<\/jats:italic>, a fusion of <jats:italic>EVT6\u2010NTRK3<\/jats:italic>, or an as\u2010yet\u2010unknown <jats:italic>KIT<\/jats:italic> mutation that affected neurogenesis. Further investigation of related genetic mutations and accumulation of data from other similar cases is needed.<\/jats:p>","DOI":"10.1111\/pin.12802","type":"journal-article","created":{"date-parts":[[2019,6,25]],"date-time":"2019-06-25T18:35:09Z","timestamp":1561487709000},"page":"414-419","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A ganglion\u2010rich gastrointestinal stromal tumor: A case report"],"prefix":"10.1111","volume":"69","author":[{"given":"Yoshiki","family":"Iemura","sequence":"first","affiliation":[{"name":"Department of Diagnostic Pathology Osaka Red Cross Hospital  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Katsushima","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Osaka Red Cross Hospital  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuki R.","family":"Kataoka","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Kyoto University Hospital  Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takaki","family":"Sakurai","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Kyoto University Hospital  Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiichi","family":"Hirota","sequence":"additional","affiliation":[{"name":"Department of Surgical Pathology Hyogo College of Medicine  Hyogo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshihide","family":"Shimada","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Osaka Red Cross Hospital  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,6,24]]},"reference":[{"key":"e_1_2_8_1_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.279.5350.577"},{"key":"e_1_2_8_1_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01296263"},{"key":"e_1_2_8_1_4_1","first-page":"846","article-title":"Gastrointestinal autonomic nerve tumors. 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