{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:20:37Z","timestamp":1740126037950,"version":"3.37.3"},"reference-count":20,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,7,21]],"date-time":"2019-07-21T00:00:00Z","timestamp":1563667200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:p>We herein report the case of a 2\u2010year\u2010old girl with neurofibromatosis type 1 (NF1), who presented with a 12\u2010cm mass in the right retroperitoneum and underwent tumor resection. Histologically, the tumor was composed of two distinct components: one was teratoma, showing mature morphology; and the other was embryonal rhabdomyosarcoma. An interphase fluorescence <jats:italic>in situ<\/jats:italic> hybridization (FISH) analysis of the rhabdomyosarcoma component revealed the absence of isochromosome 12p. Although it is well known that rhabdomyosarcoma occurs in infantile NF1, and that rhabdomyosarcoma can arise from teratoma as a somatic\u2010type malignancy, to the best of our knowledge, this is the first case of an infantile NF1 patient, who developed rhabdomyosarcoma within a retroperitoneal teratoma. The absence of chromosome 12p alteration suggests a possibility that the rhabdomyosarcoma occurred due to the NF1 background, not as a somatic\u2010type malignancy of germ cell tumor.<\/jats:p>","DOI":"10.1111\/pin.12810","type":"journal-article","created":{"date-parts":[[2019,7,22]],"date-time":"2019-07-22T06:10:33Z","timestamp":1563775833000},"page":"488-495","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Rhabdomyosarcoma arising from retroperitoneal teratoma in an infantile neurofibromatosis type 1 patient"],"prefix":"10.1111","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5709-1968","authenticated-orcid":false,"given":"Akane","family":"Aikawa","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Kanazawa Medical University  Ishikawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenichi","family":"Mizutani","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Kanazawa Medical University  Ishikawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chizuru","family":"Futatsuya","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Kanazawa Medical University  Ishikawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motona","family":"Kumagai","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Kanazawa Medical University  Ishikawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiro","family":"Shioya","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Kanazawa Medical University  Ishikawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoko","family":"Nakada","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Kanazawa Medical University  Ishikawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nozomu","family":"Kurose","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Kanazawa Medical University  Ishikawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayuki","family":"Nojima","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Kanazawa University Hospital  Ishikawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4855-4366","authenticated-orcid":false,"given":"Toyonori","family":"Tsuzuki","sequence":"additional","affiliation":[{"name":"Department of Surgical Pathology Aichi Medical University Hospital  Nagakute Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2662-0024","authenticated-orcid":false,"given":"Sohsuke","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Kanazawa Medical University  Ishikawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,7,21]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_9_1_2_1","DOI":"10.1111\/cge.12625"},{"doi-asserted-by":"publisher","key":"e_1_2_9_1_3_1","DOI":"10.1097\/PAS.0b013e318033c7c4"},{"doi-asserted-by":"publisher","key":"e_1_2_9_1_4_1","DOI":"10.1097\/00000478-200608000-00005"},{"doi-asserted-by":"publisher","key":"e_1_2_9_1_5_1","DOI":"10.1038\/modpathol.2017.97"},{"doi-asserted-by":"publisher","key":"e_1_2_9_1_6_1","DOI":"10.1016\/j.prp.2017.12.015"},{"doi-asserted-by":"publisher","key":"e_1_2_9_1_7_1","DOI":"10.1002\/pbc.25556"},{"doi-asserted-by":"publisher","key":"e_1_2_9_1_8_1","DOI":"10.1136\/jmg.39.5.311"},{"doi-asserted-by":"publisher","key":"e_1_2_9_1_9_1","DOI":"10.1097\/PAS.0b013e31826df1ab"},{"doi-asserted-by":"publisher","key":"e_1_2_9_1_10_1","DOI":"10.1002\/pbc.22397"},{"doi-asserted-by":"publisher","key":"e_1_2_9_1_11_1","DOI":"10.1002\/pbc.21748"},{"key":"e_1_2_9_1_12_1","first-page":"61","article-title":"Medulloblastoma arising from an immature teratoma of the posterior fossa. 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