{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:12:32Z","timestamp":1787839952014,"version":"build-2784847793"},"reference-count":25,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,7,21]],"date-time":"2019-07-21T00:00:00Z","timestamp":1563667200000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:p>The tumorigenesis of non\u2010ampullary duodenal epithelial tumors (NADETs) might be different between the oral and anal sides of Vater's papilla. We conducted an immunohistological review to elucidate the clinicopathological features according to the tumor location and phenotypic classification. A review of an institutional database identified 121 patients with 125 superficial NADETs. NADETs were histologically evaluated and classified into the intestinal or gastric type based on immunohistochemical analysis. Clinicopathological factors were compared based on the tumor location and phenotype. Logistic regression analysis was performed to identify independent predictors for gastric\u2010type NADETs. According to location analysis, the mucin phenotype was significantly different (oral side, intestinal\u2010type 64.8%, gastric\u2010type 35.3%; anal side, intestinal\u2010type 87.3%, gastric\u2010type 12.7%; P\u2009&lt;\u20090.01). Although the incidence of adenoma was significantly predominant in the intestinal type (75.3%), most gastric\u2010type NADETs were cancerous (64.3%). Notably, most gastric\u2010type NADETs were adenocarcinomas even when the tumor size was \u22640\u2009mm. In multivariate analysis, tumor location on the oral side (odds ratio [OR], 4.42), villous structure (OR, 6.44), and low tumor gland density (OR, 9.49) were independent predictors of gastric\u2010type tumors. Gastric\u2010type NADETs significantly differ from intestinal\u2010type NADETs in terms of tumor location, morphology, and biology.<\/jats:p>","DOI":"10.1111\/pin.12829","type":"journal-article","created":{"date-parts":[[2019,7,22]],"date-time":"2019-07-22T06:10:12Z","timestamp":1563775812000},"page":"398-406","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Clinicopathological characteristics of non\u2010ampullary duodenal tumors and their phenotypic classification"],"prefix":"10.1111","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7272-0187","authenticated-orcid":false,"given":"Masao","family":"Yoshida","sequence":"first","affiliation":[{"name":"Division of Pathology Shizuoka Cancer Center  Shizuoka Japan"},{"name":"Division of Endoscopy Shizuoka Cancer Center  Shizuoka 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