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Knowledge of age\u2010related changes is important to determine appropriate prevention, detection, and treatment strategies for various diseases observed in elderly patients. We present a review of the pathological age\u2010related non\u2010neoplastic changes in the exocrine pancreas such as pancreatic fatty replacement, lobulocentric pancreatic atrophy, pancreatic duct ectasia, and metaplasia of exocrine pancreas, as well as changes in islet cells. We have discussed common pancreatic neoplasms in elderly patients, such as pancreatic intraepithelial neoplasia (PanIN), intraductal papillary mucinous neoplasms (IPMNs), and pancreatic ductal adenocarcinoma (PDAC). Age\u2010related pathological changes play a key role in pancreatic carcinogenesis via telomere dysfunction. Further studies are warranted to clarify molecular mechanisms of pancreatic carcinogenesis in elderly patients.<\/jats:p>","DOI":"10.1111\/pin.12837","type":"journal-article","created":{"date-parts":[[2019,7,24]],"date-time":"2019-07-24T07:54:58Z","timestamp":1563954898000},"page":"450-462","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["Age\u2010related morphological changes in the pancreas and their association with pancreatic carcinogenesis"],"prefix":"10.1111","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3235-655X","authenticated-orcid":false,"given":"Yoko","family":"Matsuda","sequence":"first","affiliation":[{"name":"Department of Pathology and Host\u2010Defense Faculty of Medicine, Kagawa University  Kagawa 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