{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:20:17Z","timestamp":1740126017489,"version":"3.37.3"},"reference-count":19,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,8,9]],"date-time":"2019-08-09T00:00:00Z","timestamp":1565308800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:p>We report a case of cutaneous squamous cell carcinoma (CSCC), initially coexisting with invasive extramammary Paget's disease (EMPD), in the scrotum of an 84\u2010year\u2010old man. The patient initially had a rash and pruritus before presenting with a pedunculated scrotal mass surrounded by widespread erythema. He underwent total gastrectomy for adenocarcinoma 1 year previously and had been receiving TS\u20101 (Tegafur\/Gimeracil\/Oteracil pottasium) orally. Histopathologically, the tumor consisted of invasive SCC, with invasive EMPD in the erythematous region. From the clinical presentation and histopathological findings, we assumed that CSCC developed in the background of the EMPD. The CSCC metastasized to several inguinal lymph nodes and to the brain in the following years. While the histogenesis of each of the tumors remains to be elucidated, the fact that the CSCC rather than the EMPD metastasized to a distant site in this patient is to be noted for future treatment considerations.<\/jats:p>","DOI":"10.1111\/pin.12846","type":"journal-article","created":{"date-parts":[[2019,8,9]],"date-time":"2019-08-09T10:06:48Z","timestamp":1565345208000},"page":"619-625","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Brain metastasis from cutaneous squamous cell carcinoma coexistent with extramammary Paget's disease: A case report"],"prefix":"10.1111","volume":"69","author":[{"given":"Akiko","family":"Kitano","sequence":"first","affiliation":[{"name":"Department of Pathology Tokyo Teishin University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miki","family":"Izumi","sequence":"additional","affiliation":[{"name":"Department of Medical Education Showa University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Tamura","sequence":"additional","affiliation":[{"name":"Department of Pathology Tokyo Teishin University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mamoru","family":"Tonegawa","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Tokyo Teishin Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takafumi","family":"Etou","sequence":"additional","affiliation":[{"name":"Department of Dermatology Tokyo Teishin Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1511-5340","authenticated-orcid":false,"given":"Yukiko","family":"Kishida","sequence":"additional","affiliation":[{"name":"Department of Pathology Tokyo Teishin University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,8,9]]},"reference":[{"key":"e_1_2_9_1_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000051646"},{"key":"e_1_2_9_1_3_1","doi-asserted-by":"crossref","first-page":"84","DOI":"10.5858\/2004-128-84-EPDOTS","article-title":"Extramammary Paget disease of the scrotum with features of Bowen disease","volume":"128","author":"Quinn AM","year":"2004","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_9_1_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2004.01425.x"},{"key":"e_1_2_9_1_5_1","doi-asserted-by":"publisher","DOI":"10.5227\/skincancer.20.75"},{"key":"e_1_2_9_1_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2007.00732.x"},{"key":"e_1_2_9_1_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2008.03211.x"},{"key":"e_1_2_9_1_8_1","first-page":"307","article-title":"Invasive extramammary Paget's disease with basaloid carcinoma\u2010like component showing squamous and glandular differentiation","volume":"27","author":"Tanabe H","year":"2010","journal-title":"Jpn J Diagn Pathol"},{"key":"e_1_2_9_1_9_1","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2011.23.2.222"},{"key":"e_1_2_9_1_10_1","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2013.25.1.88"},{"key":"e_1_2_9_1_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0000000000000123"},{"key":"e_1_2_9_1_12_1","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2016.28.4.497"},{"key":"e_1_2_9_1_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000018039"},{"key":"e_1_2_9_1_14_1","first-page":"592","article-title":"Concurrent Paget's disease and basal cell carcinoma of the vulva; a case report","volume":"5","author":"Abdelbaqi M","year":"2012","journal-title":"Int J Clin Exp Pathol"},{"key":"e_1_2_9_1_15_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1453"},{"key":"e_1_2_9_1_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12949"},{"key":"e_1_2_9_1_17_1","unstructured":"National Comprehensive Cancer Network. 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