{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T17:53:43Z","timestamp":1759341223039,"version":"3.37.3"},"reference-count":31,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,10,20]],"date-time":"2019-10-20T00:00:00Z","timestamp":1571529600000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:p>Castleman\u2010Kojima disease, also known as idiopathic multicentric Castleman disease with TAFRO syndrome (iMCD\u2010TAFRO), is a recently recognized systemic inflammatory disorder with a characteristic series of clinical symptoms, including thrombocytopenia (T), anasarca (A), fever (F), reticulin fibrosis (R), and organomegaly (O). Patients with iMCD\u2010TAFRO often develop severe abdominal pain, elevated alkaline phosphatase levels, and systemic inflammation, but the etiological factors are unknown. To investigate the potential role of bacterial infection in the pathogenesis of iMCD\u2010TAFRO, we performed polymerase chain reaction (PCR) for the bacterial 16S rRNA gene with DNA extracted from liver specimens of three patients with iMCD\u2010TAFRO, four patients with amyotrophic lateral sclerosis, and seven patients with inflammatory conditions. Sequencing of the PCR product showed 99% DNA sequence identity with <jats:italic>Campylobacter jejuni<\/jats:italic> in all three patients with iMCD\u2010TAFRO and in two patients with inflammatory conditions. Immunohistochemical and electron microscopy analyses could not identify <jats:italic>C. jejuni<\/jats:italic> in patients with iMCD\u2010TAFRO. The findings indicated that <jats:italic>C. jejuni<\/jats:italic> infection is not the pathological cause of iMCD\u2010TAFRO; however, this ubiquitous bacterium may play a role in uncontrolled systemic hypercytokinemia, possibly through the development of cross\u2010reactive autoantibodies.<\/jats:p>","DOI":"10.1111\/pin.12856","type":"journal-article","created":{"date-parts":[[2019,10,21]],"date-time":"2019-10-21T04:03:55Z","timestamp":1571630635000},"page":"572-579","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Hepatic <i>Campylobacter jejuni<\/i> infection in patients with Castleman\u2010Kojima disease (idiopathic multicentric Castleman disease with thrombocytopenia, anasarca, fever, reticulin fibrosis, and organomegaly (TAFRO) syndrome)"],"prefix":"10.1111","volume":"69","author":[{"given":"Chihiro","family":"Kageyama","sequence":"first","affiliation":[{"name":"Division of Pathophysiology Okayama University 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