{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T20:51:42Z","timestamp":1760043102564,"version":"3.37.3"},"reference-count":16,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,11,14]],"date-time":"2019-11-14T00:00:00Z","timestamp":1573689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:p>We herein describe a rare case of low\u2010grade endobronchial tumor that exhibited two distinct features of typical carcinoid and acinic cell carcinoma (ACC) by immunohistochemical and ultrastructure study. ACC was suspected on transbronchial biopsy. The resected specimen showed that the tumor surface comprised an acinic cell component (40% of the tumor), and the central area comprised typical carcinoid (60% of the tumor). The acinic cell component was positive for chromogranin A, synaptophysin and alpha\u20101\u2010antichymotrypsin. Additionally, this component showed focal apical membranous staining for DOG1 and weak positivity for BCL10 and SOX10. Conversely, the carcinoid component was negative for all proteins except for chromogranin A and synaptophysin. Electron microscopy indicated zymogen\u2010type granules (600\u2013800\u2009nm in diameter) in the acinic cell component, whereas neuroendocrine\u2010type granules (200\u2013300\u2009nm in diameter) were observed in the carcinoid component. Nuclear NR4A3 immunostaining, which is highly specific for ACC of the salivary gland, was negative in this case. We conclude that the pulmonary carcinoid tumor with true zymogen\u2010type granules could be seen but showed superficial similarities to ACC based on negative nuclear staining for NR4A3. Pulmonary carcinoids encompass a wide morphological spectrum and may exhibit prominent acinic cell differentiation.<\/jats:p>","DOI":"10.1111\/pin.12869","type":"journal-article","created":{"date-parts":[[2019,11,14]],"date-time":"2019-11-14T09:16:02Z","timestamp":1573722962000},"page":"721-726","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A rare case of pulmonary typical carcinoid with prominent acinic cell differentiation, resembling acinic cell carcinoma"],"prefix":"10.1111","volume":"69","author":[{"given":"Hiroshi","family":"Watanabe","sequence":"first","affiliation":[{"name":"Departments of Surgical Pathology Kyoto Prefectural University of Medicine Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5072-2640","authenticated-orcid":false,"given":"Aya","family":"Miyagawa\u2010Hayashino","sequence":"additional","affiliation":[{"name":"Departments of Surgical Pathology Kyoto Prefectural University of Medicine Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuya","family":"Imabayashi","sequence":"additional","affiliation":[{"name":"Respiratory Medicine Kyoto Prefectural University of Medicine Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuo","family":"Kishimoto","sequence":"additional","affiliation":[{"name":"Departments of Surgical Pathology Kyoto Prefectural University of Medicine Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanori","family":"Shimomura","sequence":"additional","affiliation":[{"name":"Thoracic Surgery Kyoto Prefectural University of Medicine Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kohei","family":"Honda","sequence":"additional","affiliation":[{"name":"Departments of Surgical Pathology Kyoto Prefectural University of Medicine Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ikoi","family":"Omatsu","sequence":"additional","affiliation":[{"name":"Departments of Surgical Pathology Kyoto Prefectural University of Medicine Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eri","family":"Shimada","sequence":"additional","affiliation":[{"name":"Departments of Surgical Pathology Kyoto Prefectural University of Medicine Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayoshi","family":"Inoue","sequence":"additional","affiliation":[{"name":"Thoracic Surgery Kyoto Prefectural University of Medicine Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Takayama","sequence":"additional","affiliation":[{"name":"Respiratory Medicine Kyoto Prefectural University of Medicine Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eiichi","family":"Konishi","sequence":"additional","affiliation":[{"name":"Departments of Surgical Pathology Kyoto Prefectural University of Medicine Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,11,14]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"99","volume-title":"WHO Classification of Tumours of the Lung, Pleura, Thymus, and Heart. 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