{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T13:39:15Z","timestamp":1790948355504,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,12,23]],"date-time":"2019-12-23T00:00:00Z","timestamp":1577059200000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:p>Anaplastic variant (av) of diffuse large B\u2010cell lymphoma (DLBCL) is morphologically defined in the 2017 World Health Organization classification, but still an enigmatic disease in its clinicopathologic distinctiveness, posing the differential diagnostic problem from gray zone lymphoma (GZL) and classic Hodgkin lymphoma (cHL).<\/jats:p><jats:p>Thirty\u2010one cases previously diagnosed as avDLBCL were reassessed. Of these, 27 (87%) and 4 (13%) were node\u2010based and extranodal diseases, respectively. They were further reclassified into nodal avDLBCL (n = 18), nodal CD30+ DLBCL with T\u2010cell\/histiocyte\u2010rich large B\u2010cell lymphoma\u2010like features (CD30+ DLBCL\u2010THRLBCL) (n = 6), GZL with features intermediate between DLBCL and cHL (n = 3) and CD30+ extranodal DLBCL, NOS (n = 4). The nodal avDLBCL cases had a sheet\u2010like proliferation of large cells and\/or Hodgkin\/Reed\u2010Sternberg (HRS)\u2010like cells in 12 (67%) notably with a sinusoidal pattern in 16 (89%). They showed an expression of CD20 and\/or CD79a in all and CD30 in 15 of 18. All of them were negative for PD\u2010L1 on tumor cells, although HRS\u2010like cells showed negativity or partial loss of other B\u2010cell markers to varying degrees. The present study highlighted the distinctiveness of the nodal avDLBCL with sinusoidal pattern, but without neoplastic PD\u2010L1 expression, which provide refined diagnostic criteria for a more precise pathologic and clinical characterization of this disease.<\/jats:p>","DOI":"10.1111\/pin.12871","type":"journal-article","created":{"date-parts":[[2019,12,24]],"date-time":"2019-12-24T05:18:44Z","timestamp":1577164724000},"page":"697-705","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Anaplastic variant of diffuse large B\u2010cell lymphoma: Reappraisal as a nodal disease with sinusoidal involvement"],"prefix":"10.1111","volume":"69","author":[{"given":"Nirmeen A.","family":"Megahed","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Nagoya University Hospital  Aichi Japan"},{"name":"Department of Pathology, Faculty of Medicine Mansoura University  Mansoura 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