{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:20:22Z","timestamp":1740126022337,"version":"3.37.3"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,12,19]],"date-time":"2019-12-19T00:00:00Z","timestamp":1576713600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p>We report a histological and genetic study of concurrent oligodendroglioma and a microscopic pleomorphic xanthoastrocytoma (PXA)\u2010like lesion in a 48\u2010year\u2010old male. He presented with generalized seizure, and magnetic resonance imaging revealed a nonenhanced left frontal lobe mass suggesting low\u2010grade glioma. The patient underwent craniotomy and tumor resection. Histopathological examination of the surgical specimen showed an oligodendroglioma with a PXA\u2010like element; the latter measured 0.9\u2009mm and occupied a Virchow\u2010Robin space of the superficial cortex. The whole tumor had no elevated mitotic activity, microvascular proliferation or necrosis. Each component was immunohistochemically isocitrate dehydrogenase (IDH1)\u2010R132H positive, p53 negative and ATRX positive. Genetic analyses clarified identical <jats:italic>IDH1<\/jats:italic> G395A mutation, promoter C228T mutation and 1p\/19q codeletion in both elements. Careful integration of histology and telomerase reverse transcriptase (<jats:italic>TERT<\/jats:italic>) molecular parameters revealed that this case was an oligodendroglioma showing PXA\u2010like features, rather than a collision tumor. This case provides further insights into the gliomagenesis.<\/jats:p>","DOI":"10.1111\/pin.12880","type":"journal-article","created":{"date-parts":[[2019,12,19]],"date-time":"2019-12-19T16:17:04Z","timestamp":1576772224000},"page":"40-46","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Oligodendroglioma showing pleomorphic xanthoastrocytoma\u2010like perivascular microlesion: With <i>IDH1, TERT<\/i> promoter mutation and 1p\/19q codeletion detected in both components"],"prefix":"10.1111","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1361-4450","authenticated-orcid":false,"given":"Chiaki","family":"Murakami","sequence":"first","affiliation":[{"name":"Department of Human Pathology Gunma University Graduate School of Medicine  Gunma Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hayato","family":"Ikota","sequence":"additional","affiliation":[{"name":"Department of Human Pathology Gunma University Graduate School of Medicine  Gunma Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sumihito","family":"Nobusawa","sequence":"additional","affiliation":[{"name":"Department of Human Pathology Gunma University Graduate School of Medicine  Gunma Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Nakata","sequence":"additional","affiliation":[{"name":"Department of Pathology Johns Hopkins University School of Medicine  Baltimore MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuya","family":"Yamazaki","sequence":"additional","affiliation":[{"name":"Department of Human Pathology Gunma University Graduate School of Medicine  Gunma Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiro","family":"Hashiba","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Kiryu Kosei General Hospital  Gunma Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junko","family":"Hirato","sequence":"additional","affiliation":[{"name":"Department of Pathology Public Tomioka General Hospital  Gunma Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideaki","family":"Yokoo","sequence":"additional","affiliation":[{"name":"Department of Human Pathology Gunma University Graduate School of Medicine  Gunma Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,12,19]]},"reference":[{"volume-title":"World Health Organization classification of tumours of the central nervous system","year":"2016","author":"Louis DN","key":"e_1_2_9_2_1"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-013-1141-6"},{"key":"e_1_2_9_4_1","doi-asserted-by":"crossref","first-page":"106","DOI":"10.55418\/9781933477015","volume-title":"Tumors of the Central Nervous System. 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