{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:20:40Z","timestamp":1740126040166,"version":"3.37.3"},"reference-count":8,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,1,2]],"date-time":"2020-01-02T00:00:00Z","timestamp":1577923200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:p>Composite lymphoma is a well\u2010known diagnostic entity exhibiting the synchronous occurrence of two or more distinct types of lymphomas in the same specimen. Here we report two patients, a 14\u2010year\u2010old female (Case 1) and a 45\u2010year\u2010old male (Case 2), with mediastinal composite lymphoma, comprising nodular sclerosis classic Hodgkin lymphoma (NSCHL) and primary mediastinal large B\u2010cell lymphoma (PMBL). Both patients had a mediastinal mass, and manifested two different histologic components in the same biopsy, one characteristic of NSCHL and the other PMBL. The NSCHL areas included Hodgkin and Reed\u2013Sternberg (HRS) cells with typical immunophenotypic features (CD30\u2010positive and CD20\u2010negative), whereas the sheets of large tumor cells characteristic of PMBL were strongly and uniformly CD20\u2010positive. Interestingly, although both cases showed neoplastic PD\u2010L1 (nPD\u2010L1) positivity on the HRS cells of NSCHL, they differed regarding nPD\u2010L1 expression on the PMBL tumor cells. In Case 1, the nPD\u2010L1\u2010negative PMBL component was anatomically situated outside the NSCHL lesion. On the other hand, in Case 2, the nPD\u2010L1\u2010positive PMBL component was characterized by transitional or continuous areas with the NSCHL component. These findings suggested that nPD\u2010L1 expression may define two subtypes of PMBL that are more similar to or distinct from classic Hodgkin lymphoma.<\/jats:p>","DOI":"10.1111\/pin.12891","type":"journal-article","created":{"date-parts":[[2020,1,2]],"date-time":"2020-01-02T10:22:01Z","timestamp":1577960521000},"page":"116-122","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Diagnostic utility of programmed cell death ligand 1 (clone SP142) in mediastinal composite lymphoma: A report of two cases"],"prefix":"10.1111","volume":"70","author":[{"given":"Ayako","family":"Sakakibara","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Nagoya University Hospital  Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3738-5461","authenticated-orcid":false,"given":"Kei","family":"Kohno","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Nagoya University Hospital  Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akari","family":"Iwakoshi","sequence":"additional","affiliation":[{"name":"Department of Pathology National Hospital Organization Nagoya Medical Center  Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzuko","family":"Moritani","sequence":"additional","affiliation":[{"name":"Department of Pathology Shiga University of Medical Science Hospital  Shiga Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aya","family":"Fujishiro","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Internal Medicine Shiga University of Medical Science  Shiga 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Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshie","family":"Shimoyama","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Nagoya University Hospital  Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taishi","family":"Takahara","sequence":"additional","affiliation":[{"name":"Department of Surgical Pathology Aichi Medical University Hospital  Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emiko","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Surgical Pathology Aichi Medical University Hospital  Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akiko","family":"Ohashi","sequence":"additional","affiliation":[{"name":"Department of Surgical Pathology Aichi Medical University Hospital  Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7921-6087","authenticated-orcid":false,"given":"Akira","family":"Satou","sequence":"additional","affiliation":[{"name":"Department of Surgical Pathology Aichi Medical University Hospital  Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiichi","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Pathology and Molecular Diagnostics Aichi Cancer Center Hospital  Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoko","family":"Asano","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Nagano Prefectural Shinshu Medical Center  Nagano Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeo","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Nagoya University Hospital  Aichi 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