{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T06:23:40Z","timestamp":1781850220294,"version":"3.54.5"},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,2,6]],"date-time":"2020-02-06T00:00:00Z","timestamp":1580947200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:p>Bronchiolar adenoma (BA) of the lung is a rare benign neoplasm. Because of a chest abnormal shadow indicated by health checkup, a 77\u2010year\u2010old female nonsmoker underwent computed tomography, revealing an 8\u2009mm ground glass nodule in the peripheral field of the right lower lobe. Wedge resection of the nodule was performed, with a frozen diagnosis of primary lung adenocarcinoma. The localized, 8 \u00d7 4 \u00d7 3 mm\u2010sized, jelly\u2010like mass microscopically revealed a lepidic\u2010growing lesion composed of ciliated columnar cells, mucous cells and basal cells surrounded by mucin pool. Neither nuclear atypia nor mitotic activity was noted. Immunohistochemically, the ciliated, mucous and basal cells were positive for TTF\u20101 and p16<jats:sup>INK4a<\/jats:sup>. Mucous cells were positive for napsin A and focally expressed MUC5AC. MUC6 was negative. Basal cells were positive for CK5\/6, p40, p63 and podoplanin. Human papillomavirus genome was undetectable by <jats:italic>in situ<\/jats:italic> hybridization. Ultrastructurally, the bronchiolar epithelial tubules consisted of two layers, the inner nonciliated microvillous cells and the outer basal\u2010like cells, and some of the inner cells were filled with mucin granules in cytoplasm. Molecular analysis of the tumor failed to show driver mutations. The final diagnosis was distal\u2010type BA. The postoperative course was uneventful for 6 months.<\/jats:p>","DOI":"10.1111\/pin.12904","type":"journal-article","created":{"date-parts":[[2020,2,7]],"date-time":"2020-02-07T06:22:23Z","timestamp":1581056543000},"page":"179-185","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Distal\u2010type bronchiolar adenoma of the lung expressing p16<sup>INK4a<\/sup> \u2013 morphologic, immunohistochemical, ultrastructural and genomic analysis \u2013 report of a case and review of the literature"],"prefix":"10.1111","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1041-0391","authenticated-orcid":false,"given":"Mitsuhiro","family":"Tachibana","sequence":"first","affiliation":[{"name":"Department of Diagnostic Pathology Shimada Municipal Hospital  Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masao","family":"Saito","sequence":"additional","affiliation":[{"name":"Department 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