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The pathological database of 61 end\u2010stage renal disease patients with surgical intervention for intestinal perforation was reviewed. The correlations between CER treatment and clinicopathological factors were studied among three groups: (i) patients administered CER and with CER at the perforation site (n = 23), (ii) patients administered CER with undetected CER at the perforation site (n = 12) and (iii) patients not administered CER (n = 26). The majority of the perforation site in group 1 was in the sigmoid colon (82.6%) with significantly higher average age and more frequent CER adhesion rates to the mucosa around the perforation site than group 2. The laxative administration rate in group 1 was significantly higher than group 3 and tended to be higher than group 2. The incidence of CER\u2010related intestinal necrosis was estimated at 0.57%. CER should be used with extreme caution in elderly patients with passage disturbance.<\/jats:p>","DOI":"10.1111\/pin.12906","type":"journal-article","created":{"date-parts":[[2020,1,30]],"date-time":"2020-01-30T04:07:11Z","timestamp":1580357231000},"page":"270-279","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Intestinal necrosis related to administration of cation exchange resin without sorbitol: A retrospective analysis of 61 patients with end\u2010stage renal diseases"],"prefix":"10.1111","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7173-8553","authenticated-orcid":false,"given":"Keigo","family":"Murakami","sequence":"first","affiliation":[{"name":"Department of Pathology Tohoku University Graduate School of Medicine  Miyagi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Division of 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