{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:20:22Z","timestamp":1740126022685,"version":"3.37.3"},"reference-count":17,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,2,12]],"date-time":"2020-02-12T00:00:00Z","timestamp":1581465600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:p>Primary splenic low\u2010grade B\u2010cell lymphoma of the red pulp comprises hairy cell leukemia (HCL) and splenic B\u2010cell lymphoma\/leukemia, unclassifiable (SPLL\u2010U). SPLL\u2010U is a rare disease that includes subtypes of a hairy cell leukemia\u2010variant (HCL\u2010v), splenic diffuse red pulp small B\u2010cell lymphoma (SDRPL) and other types that are known as narrow sense SPLL\u2010U (SPLL\u2010U\u2010NS). Notably, limited information is available regarding the <jats:italic>BRAF<\/jats:italic> mutation (V600E) and cyclin D3 expression in subtypes of SPLL\u2010U. Therefore, we performed a pathological analysis of the <jats:italic>BRAF<\/jats:italic> mutation (V600E) and characterized pathological features of SPLL\u2010U. We reviewed the pathological findings of 12 SPLL\u2010U cases. The 12 cases considered included two cases of HCL\u2010v, six cases of SPLL\u2010U\u2010NS and four undetermined cases. The <jats:italic>BRAF<\/jats:italic> mutation (V600E) was detected in three cases, which were all SPLL\u2010U\u2010NS. Cases with the <jats:italic>BRAF<\/jats:italic> mutation (V600E) have increased levels of CD103 expression and decreased cyclin D3 and cyclin D1 expression compared with cases that lacked the <jats:italic>BRAF<\/jats:italic> mutation. These findings suggest that the <jats:italic>BRAF<\/jats:italic> mutation might play a significant role in SPLL\u2010U. Therefore, the significance of the <jats:italic>BRAF<\/jats:italic> mutation should be evaluated via genomic or transcriptional analyses of a large cohort of SPLL\u2010U patients.<\/jats:p>","DOI":"10.1111\/pin.12909","type":"journal-article","created":{"date-parts":[[2020,2,13]],"date-time":"2020-02-13T05:25:39Z","timestamp":1581571539000},"page":"280-286","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Clinicopathological analysis of splenic red pulp low\u2010grade B\u2010cell lymphoma"],"prefix":"10.1111","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0983-2551","authenticated-orcid":false,"given":"Takaharu","family":"Suzuki","sequence":"first","affiliation":[{"name":"Department of Pathology Kurume University,\u00a0School of Medicine  Fukuoka Japan"},{"name":"Department of Hematology, Endocrinology and Metabolism, Faculty of Medicine Niigata University  Niigata 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