{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:20:24Z","timestamp":1740126024664,"version":"3.37.3"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,2,26]],"date-time":"2020-02-26T00:00:00Z","timestamp":1582675200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004330","name":"Smoking Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004330","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:p>Most breast cancers are derived from the luminal epithelium, which composes the inside of the breast ductal structure. Ductal carcinoma in situ (DCIS) leads to invasive ductal carcinoma, but noncancerous intraductal proliferative lesions are also a risk factor for ductal carcinoma. The transforming growth factor beta (TGFB) signaling pathway behaves as a tumor suppressor in the early stage of cancer, and conversely as a tumor growth factor in invasive stages in several cancers. In this study, we performed immunohistochemistry with an antibody that detects the cytoplasmic region of TGFB receptor 1 (TGFBR1) and elucidated TGFBR1 protein expression in luminal epithelial cells of noncancerous breast ducts and in several cases of DCIS and invasive carcinoma. TGFBR1 expression was higher in noncancerous breast tissue than in cancerous tissue, and a difference in expression was also seen among histological subtypes. Comparing the expression level of TGFBR1 in cancer cells and clinico\u2010pathological parameters, cases expressing low TGFBR1 tended to show low estrogen receptor expression, large tumor size (\u226510\u2009mm), and a high Ki67 labeling index. These data suggested that TGFBR1 protein expression may be related to the suppression of breast cancer cell growth.<\/jats:p>","DOI":"10.1111\/pin.12914","type":"journal-article","created":{"date-parts":[[2020,2,27]],"date-time":"2020-02-27T06:01:00Z","timestamp":1582783260000},"page":"330-339","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The relation between anti\u2010TGBFR1 immunohistochemical reaction and low Ki67, small tumor size and high estrogen receptor expression in invasive breast cancer"],"prefix":"10.1111","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9192-4740","authenticated-orcid":false,"given":"Ritsuko","family":"Nakamura","sequence":"first","affiliation":[{"name":"Department of Molecular and Cellular Pathology, Graduate School of Medical Sciences Kanazawa University  Ishikawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeru","family":"Oyama","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Pathology, Graduate School of Medical Sciences Kanazawa University  Ishikawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masafumi","family":"Inokuchi","sequence":"additional","affiliation":[{"name":"Department of Breast Oncology, Division of Cancer Medicine, Graduate School of Medical Sciences Kanazawa University  Ishikawa Japan"},{"name":"Department of Breast and Endocrine Surgery Kanazawa Medical University  Ishikawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoko","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Department of Breast Oncology, Division of Cancer Medicine, Graduate School of Medical Sciences Kanazawa University  Ishikawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miki","family":"Hirata","sequence":"additional","affiliation":[{"name":"Department of Breast Oncology, Division of Cancer Medicine, Graduate School of Medical Sciences Kanazawa University  Ishikawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroko","family":"Kawashima","sequence":"additional","affiliation":[{"name":"Radiology Division Kanazawa University Hospital  Ishikawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroko","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Diagnostic Pathology Kanazawa University Hospital  Ishikawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoh","family":"Dobashi","sequence":"additional","affiliation":[{"name":"Department of Pathology Jichi Medical University Saitama Medical Center Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akishi","family":"Ooi","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Pathology, Graduate School of Medical Sciences Kanazawa University  Ishikawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,2,26]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197202)29:2<338::AID-CNCR2820290212>3.0.CO;2-U"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198501173120303"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI45014"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1001-117"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.07.001"},{"key":"e_1_2_9_7_1","first-page":"2727","article-title":"Type I transforming growth factor beta receptor maps to 9q22 and exhibits a polymorphism and a rare variant within a polyalanine tract","volume":"58","author":"Pasche B","year":"1998","journal-title":"Cancer Res"},{"key":"e_1_2_9_8_1","first-page":"5678","article-title":"TbetaR\u2010I(6A) is a candidate tumor susceptibility allele","volume":"59","author":"Pasche B","year":"1999","journal-title":"Cancer Res"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.11.524"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-009-9906-7"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-07-5424"},{"key":"e_1_2_9_12_1","first-page":"4805","article-title":"Transforming growth factor beta type I receptor kinase mutant associated with metastatic breast cancer","volume":"58","author":"Chen T","year":"1998","journal-title":"Cancer Res"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-0030"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2016.07.002"},{"volume-title":"The 18th Edition. Kanehara & Co. Ltd","year":"2018","author":"Japanese Breast Cancer Society","key":"e_1_2_9_15_1"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.12649"},{"key":"e_1_2_9_17_1","first-page":"155","article-title":"Prognostic and predictive factors in breast cancer by immunohistochemical analysis","volume":"11","author":"Allred DC","year":"1998","journal-title":"Mod Pathol"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.50.9984"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdx308"},{"key":"e_1_2_9_20_1","unstructured":"2019 R Foundation for Statistical Computing Vienna Austria R Core Team R: A Language and Environment for Statistical Computing"},{"key":"e_1_2_9_21_1","first-page":"683","article-title":"Immunohistochemical expression of TGF beta (TGF\u2010\u03b2), TGF beta receptor 1 (TGFBR1), and Ki67 in intestinal variant of gastric adenocarcinomas","volume":"53","author":"Docea AO","year":"2012","journal-title":"Rom J Morphol Embryol"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10911-011-9216-2"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0932636100"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10911-011-9203-7"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)62985-9"},{"key":"e_1_2_9_26_1","first-page":"35","article-title":"The expression patterns of ER, PR, HER2, CK5\/6, EGFR, Ki\u201067 and AR by immunohistochemical analysis in breast cancer cell lines","volume":"4","author":"Subik K","year":"2010","journal-title":"Breast Cancer"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-016-2911-z"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13438"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-10-365"}],"container-title":["Pathology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpin.12914","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pin.12914","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pin.12914","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pin.12914","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T04:58:44Z","timestamp":1693976324000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pin.12914"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,26]]},"references-count":28,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["10.1111\/pin.12914"],"URL":"https:\/\/doi.org\/10.1111\/pin.12914","archive":["Portico"],"relation":{},"ISSN":["1320-5463","1440-1827"],"issn-type":[{"type":"print","value":"1320-5463"},{"type":"electronic","value":"1440-1827"}],"subject":[],"published":{"date-parts":[[2020,2,26]]},"assertion":[{"value":"2019-08-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}