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To examine a strong proliferative lesion\u2010promoting effect in the lung, the effects of left pulmonary ligation on lung proliferative lesions induced by 4\u2010(methylnitrosamino)\u20101\u2010(3\u2010pyridyl)\u20101\u2010butanone (NNK) were examined for 12 weeks. The number of proliferative lesions induced by NNK in the right lung after left pulmonary ligation increased significantly after 12 weeks, indicated by an increase in the weight of the right lung. In addition, several messenger RNA (mRNA) markers, including insulin growth factor 1, were highly expressed in the right lung on the seventh day after left ligation. These experiments demonstrated the clear proliferative lesion\u2010promoting effects of pulmonary ligation on the induction of the expression of mRNAs related to the cell cycle, cell division and mitosis. However, the proliferative lesion\u2010promoting effects were not strong enough to allow a shortened experimental period for the establishment of the lung bioassay model. The results also indicated the necessity to pay attention to the possibility of a recurrence of lung cancer in the residual lung after resection in humans.<\/jats:p>","DOI":"10.1111\/pin.12915","type":"journal-article","created":{"date-parts":[[2020,2,21]],"date-time":"2020-02-21T10:14:11Z","timestamp":1582280051000},"page":"340-347","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Lung proliferative lesion\u2010promoting effects of left pulmonary ligation in A\/J female mice"],"prefix":"10.1111","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8117-0495","authenticated-orcid":false,"given":"Masanao","family":"Yokohira","sequence":"first","affiliation":[{"name":"Oncology Pathology, Department of Pathology and Host\u2010Defense, Faculty of Medicine Kagawa University  Kagawa 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