{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T15:38:07Z","timestamp":1787585887584,"version":"build-2736575974"},"reference-count":54,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,5,4]],"date-time":"2020-05-04T00:00:00Z","timestamp":1588550400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:p>Epstein\u2013Barr virus (EBV) is prevalent among healthy individuals, and is implicated in numerous reactive and neoplastic processes in the immune system. The authors originally identified a series of senile or age\u2010related EBV\u2010associated B\u2010cell lymphoproliferative disorders (LPD) bearing a resemblance to immunodeficiency\u2010associated ones. These LPDs may be associated with immune senescence and are now incorporated into the revised 4th edition of 2017 WHO lymphoma classification as EBV\u2010positive (EBV+) diffuse large B\u2010cell lymphoma (DLBCL), not otherwise specified (NOS). These EBV+ B\u2010cells often have a Hodgkin\/Reed\u2010Sternberg (HRS)\u2010like appearance and are shared beyond the diagnostic categories of mature B\u2010cell neoplasms, mature T\u2010cell neoplasms, classic Hodgkin lymphoma, and immunodeficiency\u2010associated LPD. In addition, peculiar new diseases, such as EBV+ mucocutaneous ulcer and EBV+ DLBCL affecting the young, were recognized. On the other hand, lymphoma classification is now evolving in accord with deeper understanding of the biology of programmed death ligand 1 (PD\u2010L1). Assessing PD\u2010L1 positivity by staining with the anti\u2010PD\u2010L1 monoclonal antibody SP142 provides new insight by discriminating between immune evasion and senescence or immunodeficiency. The aim of the present review is to briefly summarize the diagnostic use of immunostaining with SP142 in malignant lymphomas and\/or LPDs that feature tumor and nonmalignant large B\u2010cells harboring EBV.<\/jats:p>","DOI":"10.1111\/pin.12946","type":"journal-article","created":{"date-parts":[[2020,5,5]],"date-time":"2020-05-05T05:31:30Z","timestamp":1588656690000},"page":"481-492","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Age\u2010related EBV\u2010associated B\u2010cell lymphoproliferative disorders and other EBV + lymphoproliferative diseases: New insights into immune escape and immunodeficiency through staining with anti\u2010PD\u2010L1 antibody clone SP142"],"prefix":"10.1111","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2117-1266","authenticated-orcid":false,"given":"Ayako","family":"Sakakibara","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory 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