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This study aims to clarify the relationships between oxidative stress\u2010induced factors and HCC progression. The clinicopathological factors were compared with immunohistochemistry OGG1 and 8\u2010OHdG expressions in 86 resected HCC specimens. High 8\u2010OHdG expression was associated with high serum aspartate transaminase and total bilirubin levels, as well as a low platelet count, compared with low 8\u2010OHdG expression. Histological liver cirrhosis and poor differentiation were more frequent in patients with high 8\u2010OHdG expression than in those with low 8\u2010OHdG expression. The 8\u2010OHdG was negatively correlated with OGG1 expression in HCC patients. Therefore, we classified the patients into two groups, low OGG1\/high 8\u2010OHdG group and the other group. The patients with low OGG1\/high 8\u2010OHdG expressions had worse prognosis than those with the other expressions. Our results showed that low OGG1\/high 8\u2010OHdG expressions in nuclei influence HCC patient outcomes. Evaluating the patterns of OGG1 and 8\u2010OHdG expressions might provide pivotal prognostic biomarkers in patients with HCC.<\/jats:p>","DOI":"10.1111\/pin.12952","type":"journal-article","created":{"date-parts":[[2020,5,18]],"date-time":"2020-05-18T05:21:50Z","timestamp":1589779310000},"page":"533-541","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Prognostic impact of 8\u2010hydroxy\u2010deoxyguanosine and its repair enzyme 8\u2010hydroxy\u2010deoxyguanosine DNA glycosylase in hepatocellular carcinoma"],"prefix":"10.1111","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5121-682X","authenticated-orcid":false,"given":"Kyohei","family":"Yugawa","sequence":"first","affiliation":[{"name":"Department of Surgery and Science, Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"},{"name":"Department of Anatomic Pathology, Graduate School of Medical Sciences Kyushu University  Fukuoka 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