{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T14:52:43Z","timestamp":1771512763836,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,7,7]],"date-time":"2020-07-07T00:00:00Z","timestamp":1594080000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:p>Pulmonary tumor thrombotic microangiopathy (PTTM) is histologically characterized by micro tumor cell embolism and intimal fibrocellular proliferation of pulmonary arteries or arterioles. We report a secondary case of PTTM associated with extramammary Paget's disease (EMPD). The patient was a 72\u2010year\u2010old man with exertional dyspnea. Clinical examinations found he had pulmonary hypertension and multiple osteolytic lesions of vertebra. Cytological analysis of pulmonary wedge artery sample detected malignant cells and he was dead before treatment was started. Multiple tumor embolisms (&gt;17) were identified in pulmonary arteries or arterioles at autopsy, consistent with PTTM. Metastatic nodules were found in liver and lymph node. Furthermore, disseminated carcinomatosis of the bone marrow (DCBM) was seen. Immunostaining results pointed out that tumor cells possessed mammary gland phenotype. He had 4\u2010years history of EMPD in the left axilla without recurrence, and immunohistochemistry results were the same as the autopsy specimen. Thus, we diagnosed the primary site of PTTM to be EMPD. Our case highlights the usefulness of the recent proposed classification of PTTM, potential association between PTTM and DCBM, and the necessity for long\u2010term follow\u2010up in EMPD. EMPD can rarely cause PTTM to manifest as a paraneoplastic syndrome.<\/jats:p>","DOI":"10.1111\/pin.12980","type":"journal-article","created":{"date-parts":[[2020,7,8]],"date-time":"2020-07-08T05:28:08Z","timestamp":1594186088000},"page":"680-685","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Pulmonary tumor thrombotic microangiopathy associated with extramammary Paget's disease: An autopsy case report"],"prefix":"10.1111","volume":"70","author":[{"given":"Yuzo","family":"Oyama","sequence":"first","affiliation":[{"name":"Department of Diagnostic Pathology Oita University  Oita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2959-8002","authenticated-orcid":false,"given":"Haruto","family":"Nishida","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Oita University  Oita 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