{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T05:05:21Z","timestamp":1770354321497,"version":"3.49.0"},"reference-count":22,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,7,9]],"date-time":"2020-07-09T00:00:00Z","timestamp":1594252800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:p>Follicular T\u2010cell lymphoma (FTCL) is considered to originate from follicular helper T\u2010cell (Tfh) cells. Angioimmunoblastic T\u2010cell lymphoma (AITL) and peripheral T\u2010cell lymphomas with the Tfh phenotype, derived from Tfh cells, often harbor <jats:italic>RHOA<\/jats:italic> G17V mutation. We investigated whether <jats:italic>RHOA<\/jats:italic> mutations affect the clinicopathological features of FTCL. We performed deep sequencing and Sanger sequencing for <jats:italic>RHOA<\/jats:italic> exon 2 in 16 cases of FTCL. Nine cases showed <jats:italic>RHOA<\/jats:italic> mutations, including eight with c.G50T, p.Gly17Val and one with c.G50A, p.Gly17Glu, c.A52G, p.Lys18Glu, c.T102C, p.Tyr34Tyr and c.G145T, p.Asp49Tyr. Compared to the <jats:italic>RHOA<\/jats:italic> mutation\u2010negative group, the <jats:italic>RHOA<\/jats:italic> mutation\u2010positive group had a higher tendency for B\u2010immunoblasts (<jats:italic>P<\/jats:italic> = 0.06), the AITL component (<jats:italic>P<\/jats:italic> = 0.09), and higher positive rate for CD10 (<jats:italic>P<\/jats:italic> = 0.09) and BCL6 (<jats:italic>P<\/jats:italic> = 0.09), and a significantly higher positive rate for CXCL13 (<jats:italic>P<\/jats:italic> = 0.04). Although not statistically significant, the <jats:italic>RHOA<\/jats:italic> mutation\u2010positive group showed higher values for almost all characteristic AITL features. There was no significant difference in overall survival between <jats:italic>RHOA<\/jats:italic> mutation\u2010positive and \u2010negative groups. The <jats:italic>RHOA<\/jats:italic> mutation may play an important role in clinicopathological characteristics and lymphomagenesis of FTCL. A more detailed investigation is needed to highlight the importance of <jats:italic>RHOA<\/jats:italic> mutations in FTCL.<\/jats:p>","DOI":"10.1111\/pin.12981","type":"journal-article","created":{"date-parts":[[2020,7,10]],"date-time":"2020-07-10T06:34:29Z","timestamp":1594362869000},"page":"653-660","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["<i>RHOA<\/i> mutation in follicular T\u2010cell lymphoma: Clinicopathological analysis of 16 cases"],"prefix":"10.1111","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2356-3725","authenticated-orcid":false,"given":"Hiroaki","family":"Miyoshi","sequence":"first","affiliation":[{"name":"Department of Pathology, School of Medicine Kurume University  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mamiko","family":"Sakata\u2010Yanagimoto","sequence":"additional","affiliation":[{"name":"Department of Hematology, Faculty of Medicine University of Tsukuba  Ibaraki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1044-1654","authenticated-orcid":false,"given":"Joji","family":"Shimono","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Medicine Kurume University  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriaki","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Medicine Kurume University  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiichiro","family":"Hattori","sequence":"additional","affiliation":[{"name":"Department of Hematology, Faculty of Medicine University of Tsukuba  Ibaraki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumiko","family":"Arakawa","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Medicine Kurume University  Fukuoka 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