{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T11:46:20Z","timestamp":1787312780291,"version":"build-2736575974"},"reference-count":17,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,9,3]],"date-time":"2020-09-03T00:00:00Z","timestamp":1599091200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["19K07438"],"award-info":[{"award-number":["19K07438"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Although cases with metachronous or synchronous co\u2010occurrence of classic Hodgkin lymphoma (CHL) and B\u2010cell non\u2010Hodgkin lymphoma (B\u2010NHL) have been reported, few reports have analyzed the clonal relationship between both lesions in detail, especially in Epstein\u2013Barr virus (EBV)\u2010positive settings. Here, we report a case of a 38\u2010year\u2010old male with CHL, followed by the recurrence of EBV\u2010positive mucocutaneous ulcers of the large intestine and EBV\u2010positive diffuse large B\u2010cell lymphoma in the liver. Surprisingly, polymerase chain reaction analysis for immunoglobulin heavy chain gene rearrangement revealed that all lesions were clonally distinct. We further reviewed the literature on synchronous and metachronous co\u2010occurrence of CHL and B\u2010NHL in EBV\u2010positive settings. In contrast to EBV\u2010negative settings, all evaluable cases showed clonally distinct multiple lesions. These findings suggest that histologically and clonally distinct B\u2010cells could simultaneously proliferate in EBV\u2010associated settings, providing a new insight into the pathogenesis of EBV\u2010associated lymphoproliferative disorders.<\/jats:p>","DOI":"10.1111\/pin.13012","type":"journal-article","created":{"date-parts":[[2020,9,3]],"date-time":"2020-09-03T09:33:13Z","timestamp":1599125593000},"page":"893-898","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Co\u2010occurrence of EBV\u2010positive classic Hodgkin lymphoma and B\u2010cell lymphomas of different clonal origins: A case report and literature review"],"prefix":"10.1111","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1205-858X","authenticated-orcid":false,"given":"Kennosuke","family":"Karube","sequence":"first","affiliation":[{"name":"Department of Pathology and Cell Biology, Graduate School of Medicine and Faculty of Medicine University of the Ryukyus  Okinawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuyoshi","family":"Takatori","sequence":"additional","affiliation":[{"name":"Department of Pathology and Cell Biology, Graduate School of Medicine and Faculty of Medicine University of the Ryukyus  Okinawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3738-5461","authenticated-orcid":false,"given":"Kei","family":"Kohno","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Nagoya University Hospital  Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeaki","family":"Tomoyose","sequence":"additional","affiliation":[{"name":"Department of Hematology Okinawa Prefectural Nanbu Medical Center and Children's Medical Center  Okinawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuiku","family":"Ohshiro","sequence":"additional","affiliation":[{"name":"Department of Hematology Okinawa Prefectural Nanbu Medical Center and Children's Medical Center  Okinawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iwao","family":"Nakazato","sequence":"additional","affiliation":[{"name":"Department of Pathology Okinawa Prefectural Nanbu Medical Center and Children's Medical Center  Okinawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(14)70153-6"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403202"},{"key":"e_1_2_9_4_1","doi-asserted-by":"crossref","first-page":"304","DOI":"10.3390\/cancers10090304","article-title":"Classic Hodgkin lymphoproliferative diseases clonally unrelated to 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