{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:20:46Z","timestamp":1740126046363,"version":"3.37.3"},"reference-count":17,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,9,10]],"date-time":"2020-09-10T00:00:00Z","timestamp":1599696000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Extrahepatic bile duct (EHBD) cancer is a devastating cancer, and more common in Asian countries than in Western countries. Histological grading continues to be a highly relevant factor in prognosis and management of many kinds of cancer, however no uniform histological grading system exists for EHBD cancer. Histological heterogeneity within tumors is a problem in the evaluation of EHBD cancer. We developed an EHBD histological grading scheme to evaluate tumor differentiation pattern, and statistically analyzed its relationship with prognosis. In the present study, 257 surgically resected EHBD cancers were reviewed and their histological glandular differentiation (HGD) pattern was scored, and then we summed up the most and second most predominant scores. These scores were statistically analyzed for their relationship with patient prognosis. Patients showed a trend of shortening recurrence\u2010free survival (RFS) and overall survival (OS) in association with higher HGD scores. In multivariate analyses, HGD score was determined to be an influential factor in RFS (<jats:italic>P<\/jats:italic>\u2009=\u20090.00041) and OS (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001). In addition, combining HGD score and lymph node status correctly stratified patient prognosis in RFS. In conclusion, this new HGD scoring system is highly practical and has powerful prognostic value for EHBD cancer.<\/jats:p>","DOI":"10.1111\/pin.13014","type":"journal-article","created":{"date-parts":[[2020,9,28]],"date-time":"2020-09-28T20:08:25Z","timestamp":1601323705000},"page":"857-864","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Histological evaluation of tumor differentiation score and prognosis of extrahepatic bile duct cancer: A proposal for a new histological grading system"],"prefix":"10.1111","volume":"70","author":[{"given":"Toshihide","family":"Komatsubara","sequence":"first","affiliation":[{"name":"Department of Pathology Jichi Medical University  Tochigi\u2010ken Japan"},{"name":"Department of Surgery Jichi Medical University  Tochigi\u2010ken Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasunaru","family":"Sakuma","sequence":"additional","affiliation":[{"name":"Department of Surgery Jichi Medical University  Tochigi\u2010ken Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naohiro","family":"Sata","sequence":"additional","affiliation":[{"name":"Department of Surgery Jichi Medical University  Tochigi\u2010ken Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4522-9007","authenticated-orcid":false,"given":"Noriyoshi","family":"Fukushima","sequence":"additional","affiliation":[{"name":"Department of Pathology Jichi Medical University  Tochigi\u2010ken Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,9,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199910283411807"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67530-7"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000251366.62632.d3"},{"key":"e_1_2_9_5_1","first-page":"87","volume-title":"TNM Classification of Malignant Tumours","author":"Brierley J","year":"2017"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711390210"},{"key":"e_1_2_9_7_1","unstructured":"HrubanRH AdsayNV EspositoIet al. Pancreatic ductal adenocarcinoma. In: The WHO Classification of Tumours Editorial Board eds.WHO Classification of Tumours: Digestive System Tumours 5th edn. Lyon: International Agency for Research on Cancer;2019. ISBN : 978\u201092\u2010832\u20104499\u20108."},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000163360.40357.f1"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2015.02.006"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2012.244"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.10870"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199901000-00010"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199911000-00008"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(84)90013-8"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197701)39:1<232::AID-CNCR2820390137>3.0.CO;2-Y"},{"key":"e_1_2_9_16_1","first-page":"614","article-title":"Changing patterns in diagnosis and management of bile duct cancer","volume":"211","author":"Tompkins RK","year":"1990","journal-title":"Ann Surg"},{"key":"e_1_2_9_17_1","first-page":"211","article-title":"Carcinoma at the junction of the main hepatic ducts","volume":"38","author":"Whelton MJ","year":"1969","journal-title":"Q J Med"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(76)90044-1"}],"container-title":["Pathology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pin.13014","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pin.13014","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pin.13014","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T20:02:20Z","timestamp":1693857740000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pin.13014"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,10]]},"references-count":17,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["10.1111\/pin.13014"],"URL":"https:\/\/doi.org\/10.1111\/pin.13014","archive":["Portico"],"relation":{},"ISSN":["1320-5463","1440-1827"],"issn-type":[{"type":"print","value":"1320-5463"},{"type":"electronic","value":"1440-1827"}],"subject":[],"published":{"date-parts":[[2020,9,10]]},"assertion":[{"value":"2020-07-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}