{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T07:47:34Z","timestamp":1778917654047,"version":"3.51.4"},"reference-count":12,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,9,21]],"date-time":"2020-09-21T00:00:00Z","timestamp":1600646400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:p>Mesothelioma <jats:italic>in situ<\/jats:italic> (MIS) has recently been investigated as a distinct phase of mesothelioma carcinogenesis. The diagnostic criteria proposed for MIS include a loss of BRCA1\u2010associated protein 1 (<jats:italic>BAP1<\/jats:italic>) expression detected by immunohistochemistry (IHC). However, the length of time that MIS typically remains an <jats:italic>in situ<\/jats:italic> lesion before progression to invasive disease is still unclear. Herein, we report a case of a Japanese woman in her early seventies who had suffered from recurrent pleural effusions for 15 years, during which MIS developed and progressed to invasive mesothelioma. Retrospective diagnosis of partial MIS, fully developed MIS, and invasive disease was made using BAP1 IHC on three biopsy specimens and via clinical observations with radiological images. MIS and invasive lesions revealed BAP1 loss. The interval from partial or full MIS to invasive disease was 14 and 7 years, respectively. These results support a diagnostic strategy combining histomorphology with genomic\u2010based assays including BAP1 IHC in biopsy tissues from a patient with recurrent pleural effusions.<\/jats:p>","DOI":"10.1111\/pin.13021","type":"journal-article","created":{"date-parts":[[2020,9,21]],"date-time":"2020-09-21T21:20:24Z","timestamp":1600723224000},"page":"1009-1014","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Development of mesothelioma <i>in situ<\/i> and its progression to invasive disease observed in a patient with uncontrolled pleural effusions for 15 years"],"prefix":"10.1111","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9581-5445","authenticated-orcid":false,"given":"Kouko","family":"Hidaka","sequence":"first","affiliation":[{"name":"Division of Respiratory Medicine, Department of Internal Medicine, National Institutional Hospital Kokura Medical Center  Fukuoka 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