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We investigated the protein expression of PD\u2010L1 and B7\u2010H3 and their potential correlation with histological subtype, which might help to develop new therapies targeting these immune checkpoint molecules. Expression analysis of PD\u2010L1 and B7\u2010H3 was performed by immunohistochemistry using serial tissue sections of specimens obtained from 31 patients with mesothelioma. Tumors were classified into 22 epithelioid, 6 sarcomatoid, and 3 biphasic types. Of the 31 patients, 13 (41.9%) were positive for PD\u2010L1 and 28 (90.3%) were B7\u2010H3 positive. Twelve of the 13 PD\u2010L1 positive patients were positive for B7\u2010H3. PD\u2010L1 and B7\u2010H3 were widely co\u2010expressed in biphasic and sarcomatoid type tumor cells. 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