{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T13:51:24Z","timestamp":1780667484256,"version":"3.54.1"},"reference-count":19,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:p><jats:italic>EWSR1<\/jats:italic>\u2010<jats:italic>CREM<\/jats:italic> gene fusions were recently discovered in several mesenchymal and epithelial tumors, including myxoid mesenchymal tumors of the central nervous system, rare cases of soft tissue clear cell sarcoma and angiomatoid fibrous histiocytoma, and hyalinizing clear cell carcinoma, which implicates the potential phenotypic diversities of tumors harboring an <jats:italic>EWSR1<\/jats:italic>\u2010<jats:italic>CREM<\/jats:italic> fusion. We herein present an exceedingly indolent pulmonary mesenchymal tumor showing distinctive clinicopathological features. This tumor histologically displayed a small nest and alveolar pattern consisting of monomorphic clear cells intermingled with dilated anastomosing vasculature. Immunophenotypically, tumor cells were positive for vimentin and focally positive for synaptophysin, but negative for many immunohistochemical panels including keratins, EMA, desmin, mesothelial markers, melanotic markers, smooth muscle actin, inhibin and S\u2010100 protein. Interestingly, RNA sequencing identified an in\u2010frame <jats:italic>EWSR1<\/jats:italic>\u2010<jats:italic>CREM<\/jats:italic> fusion, which was confirmed by subsequent real\u2010time\/reverse transcription polymerase chain reaction and fluorescence in situ hybridization assay. Clinical follow\u2010up showed no evidence of recurrence and metastasis. Our pathological findings further expand the phenotypic spectrum of tumors associated with <jats:italic>EWSR1<\/jats:italic>\u2010<jats:italic>CREM<\/jats:italic> fusions, implying the emergence of a possible novel tumor entity.<\/jats:p>","DOI":"10.1111\/pin.13030","type":"journal-article","created":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T18:30:10Z","timestamp":1601577010000},"page":"1020-1026","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["<i>EWSR1\u2010CREM<\/i> fusion in pulmonary mesenchymal neoplasm showing distinctive clear cell morphology"],"prefix":"10.1111","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2007-0252","authenticated-orcid":false,"given":"Masato","family":"Komatsu","sequence":"first","affiliation":[{"name":"Department of Diagnostic Pathology Kobe University Graduate School of Medicine  Hyogo Japan"},{"name":"Department of Diagnostic Pathology Hyogo Cancer Center 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