{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T10:24:22Z","timestamp":1772187862147,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,10,20]],"date-time":"2020-10-20T00:00:00Z","timestamp":1603152000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>Primordial odontogenic tumor (POT) is a newly classified, mixed epithelial and mesenchymal odontogenic tumor, with only 17 reported cases to date. Herein, we report a case of POT that occurred in the right maxilla of a 10\u2010year\u2010old boy and reveal unique features in comparison with those previously reported. Radiologically, the lesion presented as a well\u2010defined, unilocular radiolucency with notable radiopaque foci on the periphery. Microscopically, the tumor was mainly composed of dental papilla\u2010like myxoid fibrous connective tissue, largely surrounded by non\u2010keratinized squamous epithelium with numerous calcified particles, and partly enclosed by inner enamel epithelium\u2010like columnar cells and enamel organ\u2010like structures accompanied with cuboidal and\/or stellate reticulum\u2010like cells. Immunohistochemically, the epithelium tested positive for cytokeratin 14 and 19. Moreover, amelogenin and ameloblastin, matrix proteins relating to enamel formation, were positive in the covering epithelium. The tumor was enucleated as a whole, and no recurrence was recorded thereafter. Although the presence of numerous calcified particles was unique, we diagnosed this lesion as POT based on the above\u2010described features. Furthermore, we emphasize the importance of the differential diagnosis of POT and other odontogenic tumors that resemble corresponding tooth germ components.<\/jats:p>","DOI":"10.1111\/pin.13036","type":"journal-article","created":{"date-parts":[[2020,10,20]],"date-time":"2020-10-20T16:08:36Z","timestamp":1603210116000},"page":"80-87","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Primordial odontogenic tumor occurred in the maxilla with unique calcifications and its crucial points for differential diagnosis"],"prefix":"10.1111","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9648-5828","authenticated-orcid":false,"given":"Kou","family":"Kayamori","sequence":"first","affiliation":[{"name":"Department of Oral Pathology, Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maiko","family":"Tsuchiya","sequence":"additional","affiliation":[{"name":"Department of Oral Diagnostic Pathology, Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuyuki","family":"Michi","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ami","family":"Kuribayashi","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Radiology, Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshinari","family":"Mikami","sequence":"additional","affiliation":[{"name":"Pax Creation Medical Lab. LLC  Iwate Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kei","family":"Sakamoto","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology, Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuya","family":"Yoda","sequence":"additional","affiliation":[{"name":"Department of Maxillofacial Surgery, Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tohru","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology, Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,10,20]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"WHO Classification of Head and Neck Tumours","author":"El\u2010Naggar AC","year":"2017"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.12451"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2015.08.019"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/pin.12543"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/pin.12601"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.13488"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.14735.1"},{"key":"e_1_2_8_9_1","first-page":"97","article-title":"Primordial odontogenic tumor of mandible: A case with proposed diagnostic criteria","volume":"43","author":"Pardhe N","year":"2018","journal-title":"Iran J Med Sci"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-018-0913-7"},{"key":"e_1_2_8_11_1","first-page":"e952","article-title":"Primordial odontogenic tumor with prominent calcifications: A rare case report","volume":"11","author":"Poomsawat S","year":"2019","journal-title":"J Clin Exp Dent"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13000-019-0867-4"},{"key":"e_1_2_8_13_1","article-title":"The challenging diagnosis of primordial odontogenic tumor","volume":"2019","author":"Teixeira LN","year":"2019","journal-title":"Case Rep Dent"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0180224"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.3353\/omp.7.19"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12125"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0722.2000.00717.x"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.dmfr.4600261"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2015.12.009"}],"container-title":["Pathology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pin.13036","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pin.13036","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pin.13036","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T01:01:13Z","timestamp":1693357273000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pin.13036"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,20]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1111\/pin.13036"],"URL":"https:\/\/doi.org\/10.1111\/pin.13036","archive":["Portico"],"relation":{},"ISSN":["1320-5463","1440-1827"],"issn-type":[{"value":"1320-5463","type":"print"},{"value":"1440-1827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,20]]},"assertion":[{"value":"2020-07-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}