{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:20:46Z","timestamp":1740126046769,"version":"3.37.3"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,10,20]],"date-time":"2020-10-20T00:00:00Z","timestamp":1603152000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>The case of 70\u2010year\u2010old man with mantle cell lymphoma (MCL) carrying t(11;14) translocation that relapsed as nodal lymphoma combining MCL and classic Hodgkin lymphoma (cHL) 9 years after autologous peripheral blood stem cell transplant (auto\u2010PBSCT) is reported. Lymph nodes contained two separate areas of MCL and cHL\u2010like components. Hodgkin and Reed\u2013Sternberg (HRS)\u2010like cells were accompanied by a prominent histiocyte background. HRS\u2010like cells were CD5<jats:sup>\u2212<\/jats:sup>, CD15<jats:sup>+<\/jats:sup>, CD20<jats:sup>\u2212<\/jats:sup>, CD30<jats:sup>+<\/jats:sup>, PAX5<jats:sup>+<\/jats:sup>, Bob.1<jats:sup>\u2212<\/jats:sup>, Oct2<jats:sup>\u2212<\/jats:sup> and EBER<jats:sup>+<\/jats:sup>. The MCL component expressed cyclin D1 and SOX11, whereas cyclin D1 and SOX11 expressions were reduced and lost, respectively, in HRS\u2010like cells. Polymerase chain reaction results showed a single clonal rearrangement of the <jats:italic>IGH<\/jats:italic> gene in MCL and cHL\u2010like components. <jats:italic>CCND1<\/jats:italic> break apart fluorescence <jats:italic>in situ<\/jats:italic> hybridization showed split signals in both MCL and HRS\u2010like cells, suggesting that MCL and cHL\u2010like components were clonally related. Acquisition of p53 expression and Epstein\u2013Barr virus (EBV)\u2010positivity was seen in HRS\u2010like cells. The patient died of disease progression with elevated hepatobiliary enzymes. The autopsy showed both MCL and cHL\u2010like components around the bile ducts, splenic white pulp and bone marrow. The two components were phenotypically distinct, but genetically related, suggesting that transformation of MCL to HRS\u2010like cells during the course of MCL in association with EBV infection.<\/jats:p>","DOI":"10.1111\/pin.13038","type":"journal-article","created":{"date-parts":[[2020,10,20]],"date-time":"2020-10-20T16:17:47Z","timestamp":1603210667000},"page":"96-101","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Mantle cell lymphoma with EBV\u2010positive Hodgkin and Reed\u2013Sternberg\u2010like cells in a patient after autologous PBSCT: Phenotypically distinct but genetically related tumors"],"prefix":"10.1111","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7330-3799","authenticated-orcid":false,"given":"Risa","family":"Kanai","sequence":"first","affiliation":[{"name":"Department of Surgical Pathology Kyoto Prefectural University of Medicine  Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5072-2640","authenticated-orcid":false,"given":"Aya","family":"Miyagawa\u2010Hayashino","sequence":"additional","affiliation":[{"name":"Department of Surgical Pathology Kyoto Prefectural University of Medicine  Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4138-1669","authenticated-orcid":false,"given":"Yukiko","family":"Shishido\u2010Hara","sequence":"additional","affiliation":[{"name":"Department of Pathology and Applied Neurobiology Kyoto Prefectural University of Medicine  Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoya","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Pathology Tokai University School of Medicine Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ikoi","family":"Omatsu","sequence":"additional","affiliation":[{"name":"Department of Surgical Pathology Kyoto Prefectural University of Medicine  Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukiko","family":"Morinaga","sequence":"additional","affiliation":[{"name":"Department of Surgical Pathology Kyoto Prefectural University of Medicine  Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Shimura","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Hematology and Oncology Kyoto Prefectural University of Medicine Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junya","family":"Kuroda","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Hematology and Oncology Kyoto Prefectural University of Medicine Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuya","family":"Imura","sequence":"additional","affiliation":[{"name":"Department of Surgical Pathology Kyoto Prefectural University of Medicine  Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8369-8800","authenticated-orcid":false,"given":"Kyoko","family":"Itoh","sequence":"additional","affiliation":[{"name":"Department of Pathology and Applied Neurobiology Kyoto Prefectural University of Medicine  Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eiichi","family":"Konishi","sequence":"additional","affiliation":[{"name":"Department of Surgical Pathology Kyoto Prefectural University of Medicine  Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,10,20]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"285","volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissue","author":"Swerdlow SH","year":"2017"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2016.1248965"},{"key":"e_1_2_8_4_1","unstructured":"SteinH PileriSA WeissLMet al.Hodgkin lymphomas: Introduction. 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