{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T20:33:19Z","timestamp":1781641999802,"version":"3.54.5"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,10,20]],"date-time":"2020-10-20T00:00:00Z","timestamp":1603152000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>Gastritis cystica profunda (GCP) is a lesion characterized by cystic gastric glands within the submucosa. Some studies have reported that GCP is a precancerous lesion. Here, we investigated the association between GCP and gastric cancer. Gastric cancer specimens were taken from 1432 patients undergoing surgery or endoscopic submucosal resection and were classified as GCP or non\u2010GCP. The clinicopathological features, immunohistochemistry and <jats:italic>in situ<\/jats:italic> hybridization expression of p53, Ki\u201067, KCNE2, Epstein\u2013Barr virus (EBV) and programmed death ligand 1 (PD\u2010L1) were compared between the two groups, as well as between GCPs and normal pyloric glands. One hundred and eighty patients (12.6%) had GCPs. In the GCP group, no cancerous lesions were found within the GCPs, but 13% were linked to GCPs and 60.2% were located above or near GCPs. Aberrant p53 expression, EBV\u2010positive cancer cells and PD\u2010L1 scores were significantly higher in the GCP group. The p53 score and Ki\u201067 labelling index were significantly higher and the KCNE2 score was significantly lower in GCPs than in pyloric glands. Although we suggest GCP is paracancerous, GCP has high proliferation activity and gastric cancer with GCP is associated with aberrant p53 and EBV. GCP is associated with aberrant p53 expression and EBV.<\/jats:p>","DOI":"10.1111\/pin.13039","type":"journal-article","created":{"date-parts":[[2020,10,21]],"date-time":"2020-10-21T07:08:01Z","timestamp":1603264081000},"page":"42-50","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Gastritis cystica profunda is associated with aberrant p53 and Epstein\u2013Barr virus in gastric cancer: A clinicopathological, immunohistochemical and <i>in situ<\/i> hybridization study"],"prefix":"10.1111","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3534-4175","authenticated-orcid":false,"given":"Hiroe","family":"Itami","sequence":"first","affiliation":[{"name":"Department of Diagnostic Pathology Nara Medical University Nara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kohei","family":"Morita","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Nara 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