{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T03:42:15Z","timestamp":1767066135893,"version":"3.37.3"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,11,25]],"date-time":"2020-11-25T00:00:00Z","timestamp":1606262400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pathology International"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>Histiocytic and dendritic cell (H\/DC) neoplasms are heterogeneous, originating from myeloid\u2010 or stromal\u2010derived cells. Multiple reports describe the cross\u2010lineage transdifferentiation of neoplastic B cells into H\/DC neoplasms. Most such cases are from Western countries, and rarely from Japan or East Asia. Here we report 17 cases of H\/DC neoplasms in Japanese patients, with analysis of t(14;18) by fluorescence in situ hybridization, and of neoplastic programmed death\u2010ligand 1 (PD\u2010L1) expression by immunostaining (clones SP142, E1J2J, and 28\u20108). These 17 cases were diagnosed according to the 2017 World Health Organization (WHO) classification, and included two histiocytic sarcomas (HS), two interdigitating cell (IDC) sarcomas, one Langerhans cell sarcoma, two dendritic cell sarcomas, and 10 follicular dendritic cell (FDC) sarcomas. No case had any past history of follicular lymphoma (FL). Two cases of HS and one IDC sarcoma, all of which were myeloid\u2010driven, were found to exhibit t(14;18). In the latter case, at 30 months after IDC sarcoma diagnosis, FL development was detected. Three (30%) FDC sarcoma cases exhibited neoplastic PD\u2010L1 expression with all the three PD\u2010L1 antibody clones. This is the first report of t(14;18) and neoplastic PD\u2010L1 expression on H\/DC neoplasms among Japanese patients, each of which appeared to be associated with HS and FDC sarcoma, respectively.<\/jats:p>","DOI":"10.1111\/pin.13044","type":"journal-article","created":{"date-parts":[[2020,11,25]],"date-time":"2020-11-25T18:59:18Z","timestamp":1606330758000},"page":"24-32","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Histiocytic and dendritic cell neoplasms: Reappraisal of a Japanese series based on t(14;18) and neoplastic PD\u2010L1 expression"],"prefix":"10.1111","volume":"71","author":[{"given":"Kanae","family":"Okada","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Nagoya University Hospital  Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taishi","family":"Takahara","sequence":"additional","affiliation":[{"name":"Department of Surgical 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